# 2s FDA Drug Approval Lookup

> 2s FDA Drug Approval Lookup is a paid API for AI agents from 2s.io, paid per call via x402, $0.0018/call, status unknown (last checked 2026-10-10).

Looks up FDA drug approval records by drug name, sponsor, or application number via OpenFDA

## Facts

- Endpoint: GET https://2s.io/api/medical/drug-approval?utm_source=zero.xyz
- Price: $0.0018/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-10
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/2s-fda-drug-approval-lookup-30c72c55
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_QtWOTHobLAWvmgwvmawzY

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability 2s-fda-drug-approval-lookup-30c72c55
```

Example prompt: Can you pull up the FDA drug approval records for Tylenol — show me the application number, sponsor, active ingredients, dosage form, and submission history?

## When to prefer this

Use this endpoint when you need authoritative FDA drug approval data including application numbers, submission history, active ingredients, dosage forms, and marketing status. Prefer over general web search when you need structured, ground-truth regulatory data from OpenFDA. Best for pharmaceutical research, compliance checks, drug identification, and regulatory lookups.

## Known failure modes

- Drug name not found in OpenFDA database — returns empty applications array
- Invalid application number format returns no results
- Overly broad query returns more results than limit allows — only first N returned
- Network timeout or OpenFDA upstream outage
- Missing required 'input' object causes validation error

## How this service works

FDA drug approval history from Drugs@FDA — the official record of FDA-approved drug applications. Give a drug name (brand or generic), an FDA application number (e.g. NDA021436), or a sponsor name, and get back each application with its products (brand name, active ingredients + strengths, dosage form, route, marketing status, therapeutic-equivalence code, reference-drug flag) and its full submission history (original approvals, supplements, status + status date, review priority). Free, public-domain US government data. The authoritative "is this drug FDA-approved, by whom, when, and in what formulations" record — point-in-time public records, not medical advice.

## Output

Returns a list of FDA drug applications matching the query, each including the application number, brand and generic names, sponsor and manufacturer names, product details (route, dosage form, active ingredients and strengths, marketing status, reference drug flag), and a full submission history with type, number, status, status date, and review priority. Also returns total count of matching records and the data source (OpenFDA).

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method",
    "queryParams"
   ],
   "properties": {
    "type": {
     "const": "http"
    },
    "method": {
     "const": "GET"
    },
    "queryParams": {
     "properties": {
      "drug": {
       "type": "string",
       "description": "Drug name — brand or generic."
      },
      "limit": {
       "type": "integer",
       "default": 5,
       "maximum": 50,
       "minimum": 1
      },
      "sponsor": {
       "type": "string",
       "description": "Sponsor / applicant name."
      },
      "applicationNumber": {
       "type": "string",
       "description": "FDA application number, e.g. NDA021436."
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/2s-fda-drug-approval-lookup-30c72c55/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from 2s.io](https://www.zero.xyz/host/2s.io/llms.txt)