# FDA Adverse Event Reports (FAERS) Search via 2s.io

> FDA Adverse Event Reports (FAERS) Search via 2s.io is a paid API for AI agents from 2s.io, paid per call via x402, $0.0024/call, status unknown (last checked 2026-09-14).

Search 9M+ FDA adverse drug event reports (since 1968) by drug name and optional MedDRA reaction term, returning report metadata, seriousness flags, patient demographics, and implicated drugs.

## Facts

- Endpoint: GET https://2s.io/api/gov/fda-drug-events
- Price: $0.0024/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 2
- Tags: x402
- Canonical page: https://www.zero.xyz/c/2s-io-66e1dfc3
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_8TCOnU3CTro3PZaLXjkxK

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability 2s-io-66e1dfc3
```

Example prompt: Pull up the FDA adverse event reports for metformin filtered to 'lactic acidosis' reactions — give me up to 25 reports with seriousness flags and patient details.

## When to prefer this

Use this endpoint when you need to search real FDA post-market drug safety data for a specific medication, optionally filtered by a specific adverse reaction type. Prefer it over general web searches for authoritative pharmacovigilance data backed by 9M+ government records since 1968.

## Known failure modes

- Drug name not found in FAERS — returns empty results
- MedDRA reaction term misspelled or not a valid preferred term — returns empty or unfiltered results
- Drug name too short (< 2 characters) — returns validation error
- Limit out of range (< 1 or > 100) — returns validation error
- OpenFDA upstream downtime — returns 5xx error

## How this service works

Adverse drug event reports from FDA's Adverse Event Reporting System (FAERS) — 9M+ records since 1968 covering serious adverse events, hospitalizations, deaths, and disabilities. Search by drug name (brand/generic/substance, all OR-matched) and optionally filter by MedDRA reaction term. Returns report ID, received date, seriousness flags, patient demographics, MedDRA-coded reactions, implicated drugs (up to 5 per report), and reporting country. Backed by OpenFDA; data is public-domain US government records.

## Output

A list of adverse drug event reports from FAERS, each containing report ID, date received, seriousness flags (hospitalization, death, disability, etc.), patient demographics, MedDRA-coded reactions, up to 5 implicated drugs, and the reporting country.

## Example request

```json
{
 "input": {
  "type": "http",
  "method": "GET",
  "queryParams": {
   "drug": "aspirin",
   "limit": 10
  }
 }
}
```

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method",
    "queryParams"
   ],
   "properties": {
    "type": {
     "const": "http"
    },
    "method": {
     "const": "GET"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "drug"
     ],
     "properties": {
      "drug": {
       "type": "string",
       "maxLength": 100,
       "minLength": 2,
       "description": "Drug name (brand, generic, or substance). Examples: \"tylenol\", \"metformin\", \"lisinopril\". Case-insensitive."
      },
      "limit": {
       "type": "integer",
       "default": 10,
       "maximum": 100,
       "minimum": 1,
       "description": "Max reports to return (1-100). Default 10."
      },
      "reaction": {
       "type": "string",
       "maxLength": 100,
       "minLength": 2,
       "description": "Optional MedDRA preferred-term reaction filter. Examples: \"headache\", \"nausea\", \"anaphylaxis\"."
      }
     },
     "additionalProperties": false
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/2s-io-66e1dfc3/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from 2s.io](https://www.zero.xyz/host/2s.io/llms.txt)