# 2s Medical Genetics Lookup

> 2s Medical Genetics Lookup is a paid API for AI agents from 2s.io, paid per call via x402, $0.00108/call, status unknown (last checked 2026-09-14).

Looks up genetic conditions or genes by name, returning structured summaries, related genes, synonyms, inheritance patterns, and cross-references from MedlinePlus Genetics.

## Facts

- Endpoint: GET https://2s.io/api/medical/genetics
- Price: $0.00108/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 2
- Tags: x402
- Canonical page: https://www.zero.xyz/c/2s-medical-genetics-lookup-17f0a93b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_byAgpj3-7h2JXgtTDycqK

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability 2s-medical-genetics-lookup-17f0a93b
```

Example prompt: Look up the genetics of cystic fibrosis — I need a summary, the inheritance pattern, related genes like CFTR, synonyms, and any ICD-10 cross-references.

## When to prefer this

Use this endpoint when an agent needs authoritative, ground-truth genetic data about a condition or gene — including inheritance patterns, synonyms, related genes, and cross-database references — sourced from the U.S. National Library of Medicine. Prefer over general web search when structured, machine-readable genetics data is required.

## Known failure modes

- No matching condition or gene found for the search term — returns empty items array
- Ambiguous term matches many results — agent may need to refine the query
- Payment failure via x402 — 402 response if USDC not provided
- Network timeout or upstream MedlinePlus unavailability — 5xx error

## How this service works

MedlinePlus Genetics (US National Library of Medicine) reference on a genetic condition or gene. Give a term (e.g. "cystic fibrosis", "BRCA1", "sickle cell") and get back the authoritative NLM record: the condition/gene name, a plain-language summary, the full set of sections (description, causes, frequency, inheritance, treatment), the inheritance pattern(s), related genes (with links), synonyms, and cross-references to other databases (OMIM, GTR, ICD-10-CM, …). Free, public-domain (NLM). Authoritative genetics reference an LLM cannot recite reliably — for clinical, patient-education, and research agents. Educational reference, not medical advice.

## Output

Returns an array of matching genetic conditions or genes, each with a plain-language summary, synonyms, related gene symbols with URLs, cross-references to databases like ICD-10-CM and GTR, inheritance patterns (e.g. autosomal recessive), and structured text sections. Also includes total result count and source attribution from MedlinePlus Genetics.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method",
    "queryParams"
   ],
   "properties": {
    "type": {
     "const": "http"
    },
    "method": {
     "const": "GET"
    },
    "queryParams": {
     "required": [
      "term"
     ],
     "properties": {
      "term": {
       "type": "string",
       "description": "Condition or gene name (e.g. \"cystic fibrosis\", \"BRCA1\")."
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/2s-medical-genetics-lookup-17f0a93b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from 2s.io](https://www.zero.xyz/host/2s.io/llms.txt)