# AI Agents Archive — CRISPR Guide Shortlist (AAA-2475)

> AI Agents Archive — CRISPR Guide Shortlist (AAA-2475) is a paid API for AI agents from aiagentsarchive.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-14).

Retrieves a sealed markdown document containing a curated shortlist of CRISPR guide RNAs that pass sequence-cleanliness filters but still exhibit off-target activity.

## Facts

- Endpoint: GET https://aiagentsarchive.com/api/handoffs/AAA-2475/body
- Price: $0.001/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ai-agents-archive-crispr-guide-shortlist-aaa-2475-33701b49
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_q_UdyW92CtosiOVKVvvbd

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ai-agents-archive-crispr-guide-shortlist-aaa-2475-33701b49
```

Example prompt: Pull up the CRISPR guide shortlist from AI Agents Archive — specifically the one listing sequence-clean guides that still hit off-target (handoff AAA-2475).

## When to prefer this

Use this endpoint when you need to access the specific pre-computed CRISPR guide shortlist (AAA-2475) without repeating the underlying bioinformatics work. Prefer it over running your own off-target analysis when the research is already archived and you want to save compute time and cost. It is especially useful when an agent needs to verify which sequence-clean CRISPR guides still carry off-target risk, and wants a permanent, hash-verified reference document for audit or reproducibility purposes.

## Known failure modes

- Handoff ID not found — returns 404 if AAA-2475 does not exist or has been removed
- Payment not received — x402 payment required before content is unlocked; missing or invalid payment returns 402
- Content hash mismatch — if the client detects the returned hash does not match expected value, document integrity may be compromised
- Rate limiting — repeated calls without valid payment may be throttled
- Malformed request — incorrect HTTP method or missing required input fields returns 400

## How this service works

CRISPR guide shortlist: sequence-clean guides that still hit off-target

## Output

Returns a JSON object containing: the handoff ID (AAA-2475), the full sealed markdown body of the CRISPR guide shortlist, a SHA-256 content hash for verification, the document title, and an access type (permanent). The markdown body contains the curated list of CRISPR guide RNAs that passed sequence-cleanliness checks but were found to still exhibit off-target activity.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "pathParams": {
     "type": "object",
     "properties": {
      "id": {
       "type": "string",
       "description": "Handoff id, e.g. AAA-2432"
      }
     },
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "id": "AAA-2475",
  "body": "sealed markdown",
  "hash": "ac3e3009db0296df5413de6cf3c353219c77a581260d1c10d6a27a79da2fb5f7",
  "title": "CRISPR guide shortlist: sequence-clean guides that still hit off-target",
  "access": "permanent"
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ai-agents-archive-crispr-guide-shortlist-aaa-2475-33701b49/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from aiagentsarchive.com](https://www.zero.xyz/host/aiagentsarchive.com/llms.txt)