# ChEMBL Drug Target & Bioactivity Lookup

> ChEMBL Drug Target & Bioactivity Lookup is a paid API for AI agents from bio.memoryapi.org, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).

Returns drug target and bioactivity data from ChEMBL (EMBL-EBI), including ChEMBL ID, max clinical phase, molecular properties, and indication class.

## Facts

- Endpoint: GET https://bio.memoryapi.org/x402/bio/targets
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/bio-memoryapi-org-b296c8bf
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_VWN0oiUWeXfKt_9dNK1TQ

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability bio-memoryapi-org-b296c8bf
```

Example prompt: Can you look up the ChEMBL target data for imatinib — I need its ChEMBL ID, max clinical phase, indication class, and key molecular properties?

## When to prefer this

Use this endpoint when you need authoritative drug target and bioactivity data from the EMBL-EBI ChEMBL database, specifically ChEMBL IDs, clinical phase status, molecular properties, and indication class. Prefer this over PubChem (CID/SMILES) when bioactivity and clinical phase data are the primary need, and over UniProt when compound-centric rather than protein-sequence data is required.

## Known failure modes

- Target or compound not found in ChEMBL returns empty or 404 response
- Ambiguous query matches multiple targets — may return unexpected results
- Payment not processed (x402) — endpoint returns 402 Payment Required
- Rate limiting if too many requests are made in quick succession
- Invalid query parameter format returns 400 Bad Request

## How this service works

Drug target and bioactivity data from ChEMBL (EMBL-EBI) — ChEMBL ID, max clinical phase, molecular properties, indication class.

## Output

Returns structured ChEMBL data for the queried drug or target, including the ChEMBL ID, maximum clinical trial phase reached, molecular properties (such as molecular weight, logP, polar surface area), and therapeutic indication class sourced from the EMBL-EBI ChEMBL database.

## Example request

```json
{
 "name": "metformin",
 "type": "label"
}
```

## Request schema (JSON Schema)

```json
{
 "properties": {
  "input": {
   "properties": {
    "method": {
     "type": "string",
     "enum": [
      "GET"
     ]
    }
   },
   "required": [
    "method"
   ]
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "example": {
  "name": "IBUPROFEN",
  "source": "ChEMBL / EMBL-EBI",
  "success": true,
  "chembl_id": "CHEMBL521",
  "max_phase": 4,
  "molecule_type": "Small molecule"
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/bio-memoryapi-org-b296c8bf/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from bio.memoryapi.org](https://www.zero.xyz/host/bio.memoryapi.org/llms.txt)