# BiotechCatalystSentinel FDA PDUFA Event Delta Feed

> BiotechCatalystSentinel FDA PDUFA Event Delta Feed is a paid API for AI agents from api.biotechcatalystsentinel.com, paid per call via x402, $0.05/call, status unknown (last checked 2026-09-15).

Returns a cursor-paginated stream of FDA drug-approval catalyst events (PDUFA date sets, extensions, and resolutions with outcomes) for US-listed biotechs, sourced from SEC filings

## Facts

- Endpoint: GET https://api.biotechcatalystsentinel.com/v1/events
- Price: $0.05/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/biotechcatalystsentinel-fda-pdufa-event-delta-feed-110eb96e
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_X3C61ln1wDSe6owebaxwU

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability biotechcatalystsentinel-fda-pdufa-event-delta-feed-110eb96e
```

Example prompt: Pull the latest FDA PDUFA catalyst events from BiotechCatalystSentinel that have come in since event ID 4820 — give me up to 200 results, including any new dates set, extensions, and final outcomes like approvals or CRLs with their SEC filing sources.

## When to prefer this

Use this endpoint when you need incremental, cursor-based access to the full history and live stream of FDA PDUFA catalyst events — including past resolutions with verified outcomes and SEC-sourced evidence — rather than just a forward-looking calendar snapshot. Ideal for agents that need to poll for changes, backfill historical event data, or build audit trails of drug approval decisions with source citations.

## Known failure modes

- Invalid or negative since cursor returns 400 error
- limit out of range (below 1 or above 500) returns 400 validation error
- No new events since cursor returns empty data array with 200 status
- Payment not provided or rejected returns 402 Payment Required
- Rate limiting or abuse returns 429 Too Many Requests
- Service unavailability returns 503 with error message

## How this service works

FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every tracked catalyst — each PDUFA date as set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source, as a since-cursor delta feed. Use when you mirror the calendar and need date changes and outcomes as they land, not a snapshot. Accuracy AND coverage are free at GET /v1/accuracy. Flat price per request.

## Output

An array of PDUFA catalyst event objects, each containing event_type (date_set, extension, approval, CRL), drug_name, company, ticker, new_date, outcome, a verbatim SEC filing quote, and an EDGAR source URL, plus result metadata and an error field. The response represents only events newer than the provided since cursor, enabling efficient incremental polling.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [],
     "properties": {
      "limit": {
       "type": "integer",
       "default": 100,
       "maximum": 500,
       "minimum": 1,
       "description": "Maximum number of events to return (1-500; default 100)."
      },
      "since": {
       "type": "integer",
       "minimum": 0,
       "description": "Cursor: return only events with an event_id greater than this (0 = from the start). Pass the last event_id you saw to page forward."
      },
      "ticker": {
       "type": "string",
       "pattern": "^\\S+$",
       "maxLength": 12,
       "minLength": 1,
       "description": "Optional server-side filter: only events whose record is filed by this ticker's issuer or exposes it as a co-filer in tickers[] (case-insensitive). Composes with since — limit counts matched events, so a filtered backlog drains without gaps. Unknown ticker returns an empty 200. Does not change the price."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object",
     "properties": {
      "data": {
       "type": "array",
       "items": {
        "type": "object",
        "required": [
         "event_id",
         "catalyst_id",
         "event_type"
        ],
        "properties": {
         "ticker": {
          "type": [
           "string",
           "null"
          ]
         },
         "applied": {
          "type": "boolean"
         },
         "company": {
          "type": [
           "string",
           "null"
          ]
         },
         "outcome": {
          "enum": [
           "approved",
           "tentative",
           "crl",
           "none_found",
           null
          ],
          "type": [
           "string",
           "null"
          ]
         },
         "tickers": {
          "type": "array",
          "items": {
           "type": "string"
          }
         },
         "event_id": {
         
… (truncated)
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "data": [
   {
    "ticker": "OTLK",
    "company": "Outlook Therapeutics, Inc.",
    "outcome": "approved",
    "event_id": 412,
    "new_date": "2025-08-27",
    "accession": "0001649989-25-000123",
    "drug_name": "ONS-5010/LYTENAVA (bevacizumab-vikg)",
    "event_type": "decision_outcome",
    "prior_date": null,
    "source_url": "https://www.sec.gov/Archives/edgar/data/1649989/...",
    "detected_at": "2025-08-27T00:00:00",
    "new_date_upcoming": false
   }
  ],
  "meta": {
   "total": 1
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/biotechcatalystsentinel-fda-pdufa-event-delta-feed-110eb96e/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.biotechcatalystsentinel.com](https://www.zero.xyz/host/api.biotechcatalystsentinel.com/llms.txt)