# CISNE Febrile Neutropenia Risk Score Calculator > CISNE Febrile Neutropenia Risk Score Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15). Computes the Carmona-Bayonas 2015 CISNE score for stable adult solid-tumor febrile neutropenia patients, returning a numeric score and risk category (low/intermediate/high). ## Facts - Endpoint: GET https://api.magentlab.com/api/calc/cisne - Price: $0.005/call - Payment: x402 - Status: unknown - Last checked: 2026-09-15 - Activations on Zero: 0 - Tags: x402 - Canonical page: https://www.zero.xyz/c/cisne-febrile-neutropenia-risk-score-calculator-0ce99274 - Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_E8KYxalc63Tq1ULGSEfkj Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently. ## How to call it through Zero Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`): ```sh zero fetch --capability cisne-febrile-neutropenia-risk-score-calculator-0ce99274 ``` Example prompt: My patient is a solid-tumor adult with febrile neutropenia who looks clinically stable. They have ECOG ≥2, stress hyperglycemia, no COPD, no chronic cardiovascular disease, no mucositis grade ≥2, and monocytes are not below 200 — can you calculate their CISNE score and tell me what risk category they fall into? ## When to prefer this Use this endpoint when you need a deterministic, citation-backed CISNE risk score for a seemingly stable adult solid-tumor febrile neutropenia patient and all six clinical flags have already been assessed by a clinician. Prefer CISNE over MASCC when the validated population (solid tumor, clinically stable) matches. Do not use for pediatric patients, hematologic malignancies, or unstable presentations. ## Known failure modes - Missing required boolean parameter returns a validation error - Passing numeric or non-boolean values for flag fields causes schema rejection - Applying the score to pediatric patients, hematologic malignancies, or unstable patients is a clinical misuse outside the instrument's validated population - Score does not incorporate clinical judgment — caller must independently verify each input flag before submission ## How this service works Carmona-Bayonas 2015 CISNE: ECOG ≥2 (2), stress hyperglycemia (2), COPD (1), chronic cardiovascular disease (1), NCI CTC mucositis ≥2 (1), monocytes <200/µL (1). Max 8. Low 0, intermediate 1–2, high ≥3. Seemingly stable adult solid-tumor febrile neutropenia only. Deterministic published score with citation; not MASCC; not an outpatient-chemotherapy or discharge order. magent does not assign ECOG, assay glucose, diagnose COPD, read an echocardiogram, grade mucositis, or count monocytes. ## Output Returns the numeric CISNE total score (0–8) and the associated risk category: low (0), intermediate (1–2), or high (≥3), based on the six caller-supplied boolean clinical flags weighted per the Carmona-Bayonas 2015 publication. ## Request schema (JSON Schema) ```json { "type": "object", "$schema": "https://json-schema.org/draft/2020-12/schema", "required": [ "input" ], "properties": { "input": { "type": "object", "required": [ "type", "method" ], "properties": { "type": { "type": "string", "const": "http" }, "method": { "enum": [ "GET", "HEAD", "DELETE" ], "type": "string" }, "headers": { "type": "object", "additionalProperties": { "type": "string" } }, "queryParams": { "type": "object", "required": [ "ecog_ge_2", "stress_hyperglycemia", "copd", "chronic_cardiovascular_disease", "mucositis_nci_ge_2", "monocytes_lt_200" ], "properties": { "copd": { "type": "boolean", "description": "COPD as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not diagnose COPD." }, "ecog_ge_2": { "type": "boolean", "description": "ECOG performance status ≥2 as assigned by the caller (Carmona-Bayonas 2015). true scores 2. magent does not assign ECOG." }, "monocytes_lt_200": { "type": "boolean", "description": "Monocytes <200 per µL as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not count monocytes." }, "mucositis_nci_ge_2": { "type": "boolean", "description": "NCI CTC mucositis grade ≥2 as assigned by the caller (Carmona-Bayonas 2015). true scores 1, not 3. magent does not grade mucositis." }, "stress_hyperglycemia": { "type": "boolean", "description": "Stress hyperglycemia as assigned by the caller (Carmona-Bayonas 2015). true scores 2. magent does not assay glucose." }, "chronic_cardiovascular_disease": { "type": "boolean", "description": "Chronic cardiovascular disease as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not read an echocardiogram." } } } }, "additionalProperties": false }, "output": { "type": "object", "required": [ "type" ], "properties": { "type": { "type": "string" }, "example": { "type": "object" } } } } } ``` ## Response schema (JSON Schema) ```json { "type": "json", "example": { "path": "/api/calc/cisne", "count": 2, "items": [ { "score": 0, "formula": "cisne", "citation": { "id": "carmona-bayonas-2015", "doi": "10.1200/JCO.2014.57.2347", "pmid": "25559804", "title": "Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study", "source": "J Clin Oncol. 2015;33(5):465-471", "authors": "Carmona-Bayonas A, Jiménez-Fonseca P, Virizuela Echaburu J, Antonio M, Font C, Biosca M, Ramchandani A, Martínez J, Hernando Cubero J, Espinosa J, Martínez de Castro E, Ghanem I, Beato C, Blasco A, Garrido M, Bonilla Y, Mondéjar R, Arcusa Lanza MÁ, Aragón Manrique I, Manzano A, Sevillano E, Castañón E, Cardona M, Gallardo Martín E, Pérez Armillas Q, Sánchez Lasheras F, Ayala de la Peña F" }, "max_score": 8, "cisne_band": "low", "components": [ { "factor": "ecog_ge_2", "points": 0, "present": false }, { "factor": "stress_hyperglycemia", "points": 0, "present": false }, { "factor": "copd", "points": 0, "present": false }, { "factor": "chronic_cardiovascular_disease", "points": 0, "present": false }, { "factor": "mucositis_nci_ge_2", "points": 0, "present": false }, { "factor": "monocytes_lt_200", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "formula_expression": "CISNE = ecog_ge_2 2 + stress_hyperglycemia 2 + copd 1 + chronic_cardiovascular_disease 1 + mucositis_nci_ge_2 1 + monocytes_lt_200 1; Carmona-Bayonas 2015; max 8; low 0, intermediate 1-2, high ≥3" }, { "score": 0, "formula": "cisne", "citation": { "id": "carmona-bayonas-2015", "doi": "10.1200/JCO.2014.57.2347", "pmid": "25559804", "title": "Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study", "source": "J Clin Oncol. 2015;33(5):465-471", "authors": "Carmona-Bayonas A, Jiménez … (truncated) ``` ## More - Live health (JSON, refreshed every minute): https://www.zero.xyz/c/cisne-febrile-neutropenia-risk-score-calculator-0ce99274/health.json - [Zero catalog index](https://www.zero.xyz/llms.txt) - [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)