# Clinical Trials Brief — LLM Digest of Newly Registered Trials

> Clinical Trials Brief — LLM Digest of Newly Registered Trials is a paid API for AI agents from oracles-production.up.railway.app, paid per call via x402, $0.25/call, status unknown (last checked 2026-09-15).

Returns an LLM-written narrative digest summarizing the most consequential newly registered clinical trials within a specified time window

## Facts

- Endpoint: GET https://oracles-production.up.railway.app/v1/clinical-trials/brief
- Price: $0.25/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/clinical-trials-brief-llm-digest-of-newly-registered-trials-10f15b01
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_Q52kETdtMt5W_RT6BOBOA

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability clinical-trials-brief-llm-digest-of-newly-registered-trials-10f15b01
```

Example prompt: Give me an AI-written digest of the most consequential newly registered clinical trials since January 1, 2025.

## When to prefer this

Use this endpoint when you need a curated, narrative-style AI summary of newly registered clinical trials rather than raw trial data. Ideal for monitoring pipelines, healthcare newsletters, or research briefings where a human-readable digest is preferred over structured records. Choose this over raw EDGAR or trial listing endpoints when the goal is insight extraction rather than data retrieval.

## Known failure modes

- No trials found in the specified window — may return an empty or minimal brief
- Invalid date-time format for 'since' parameter returns a 400 error
- Payment of $0.25 USDC not completed results in 402 Payment Required
- LLM generation failure may fall back to template-based output (generatedBy: 'template')
- Very large windows with many trials may increase latency

## How this service works

An LLM-written digest of the most consequential newly registered trials in the window.

## Output

A JSON object containing a 'brief' field with a human-readable LLM-generated narrative summarizing the most significant newly registered clinical trials, a 'generatedBy' field indicating whether it was written by an LLM or a template, and a 'basedOnChanges' integer showing how many trial registrations were analyzed to produce the digest.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "since": {
       "type": "string",
       "format": "date-time",
       "description": "Window start (default: last 30 days)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object",
     "properties": {
      "brief": {
       "type": "string"
      },
      "generatedBy": {
       "enum": [
        "llm",
        "template"
       ],
       "type": "string"
      },
      "basedOnChanges": {
       "type": "integer"
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/clinical-trials-brief-llm-digest-of-newly-registered-trials-10f15b01/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from oracles-production.up.railway.app](https://www.zero.xyz/host/oracles-production.up.railway.app/llms.txt)