# ClinicalIntelPulse Drug Interaction Checker

> ClinicalIntelPulse Drug Interaction Checker is a paid API for AI agents from clinicalintelpulse.theaslangroupllc.com, paid per call via x402, $0.15/call, status unknown (last checked 2026-09-14).

Cross-references FDA-approved drug interaction and contraindication data for two or more drugs, flagging interactions in plain language with severity ratings and recommended actions.

## Facts

- Endpoint: GET https://clinicalintelpulse.theaslangroupllc.com/api/clinical/interaction-check
- Price: $0.15/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/clinicalintelpulse-drug-interaction-checker-ab6f25ec
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_M6yEksq6qD7Nc1JFNT_JU

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability clinicalintelpulse-drug-interaction-checker-ab6f25ec
```

Example prompt: Can I safely take metformin, lisinopril, and ibuprofen together? Cross-check those three drugs for any FDA-documented interactions, tell me the severity of anything flagged, and what I should do about it.

## When to prefer this

Use this endpoint when a patient, caregiver, pharmacist, or health assistant agent needs to quickly verify whether two or more specific medications are safe to combine, with FDA-sourced severity and plain-language guidance. Prefer this over general medical knowledge lookups when you need structured, authoritative interaction data with actionable severity ratings rather than generic advice.

## Known failure modes

- Unknown or misspelled drug name returns no interaction data or an error
- Only one drug submitted when two or more are required
- Drug not found in FDA database returns empty result
- Rate limiting or payment failure returns 402 or 429 error
- Ambiguous drug name with multiple formulations may return incomplete results

## How this service works

Can these medications be taken together? Cross-references the FDA-approved drug-interaction and contraindication sections for 2+ drugs and flags possible interactions in plain language, with severity and what-to-do. For patient, caregiver, pharmacy, and health-assistant agents managing a medication list.

## Output

Returns a list of identified drug interactions between the submitted medications, each with a severity level (e.g. contraindicated, major, moderate, minor), plain-language explanation of the interaction mechanism or risk, and recommended actions (e.g. avoid combination, monitor closely, consult physician). Sourced from FDA-approved drug interaction and contraindication sections.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string"
      },
      "drugs": {
       "type": "string"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "pairwise": [
   {
    "pair": [
     "warfarin",
     "ibuprofen"
    ],
    "risk": "serious",
    "evidence": "Warfarin label — Drug Interactions (NSAIDs); Ibuprofen label — Warnings",
    "what_to_do": "Ask your doctor or pharmacist before combining these; they may suggest a safer pain reliever such as acetaminophen.",
    "what_could_happen": "Taking them together raises the risk of serious bleeding, including stomach and intestinal bleeding."
   }
  ],
  "disclaimer": "This is an automated screen of FDA label text, not a substitute for a pharmacist or doctor. Label interaction sections are not exhaustive. Always confirm with your pharmacist before combining medications.",
  "bottom_line": "This is a well-known, potentially serious combination — do not take them together without professional guidance.",
  "class_flags": [
   "Warfarin label warns about NSAIDs as a class — ibuprofen is an NSAID."
  ],
  "overall_risk": "serious",
  "query_summary": {
   "drugs": [
    "warfarin",
    "ibuprofen"
   ],
   "drugs_found": [
    "warfarin",
    "ibuprofen"
   ],
   "drugs_not_found": []
  },
  "missing_data_note": "All drugs were found in FDA data."
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/clinicalintelpulse-drug-interaction-checker-ab6f25ec/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clinicalintelpulse.theaslangroupllc.com](https://www.zero.xyz/host/clinicalintelpulse.theaslangroupllc.com/llms.txt)