# ClinicalIntelPulse Pipeline Scan

> ClinicalIntelPulse Pipeline Scan is a paid API for AI agents from clinicalintelpulse.vercel.app, paid per call via x402, $0.15/call, status unknown (last checked 2026-09-15).

Returns a broad-sweep analysis of all active Phase 2/3 clinical trials for any disease worldwide, including trial count, sponsor landscape, geographic distribution, and pipeline density across 400,000+ trials.

## Facts

- Endpoint: GET https://clinicalintelpulse.vercel.app/api/clinical/pipeline-scan
- Price: $0.15/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/clinicalintelpulse-pipeline-scan-88bf5074
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_htp5i1X3rpKxcfD2EeAtp

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability clinicalintelpulse-pipeline-scan-88bf5074
```

Example prompt: Give me a full pipeline scan for non-alcoholic steatohepatitis — I want to know how many active Phase 2 and Phase 3 trials exist worldwide, who the major sponsors are, and how geographically distributed the activity is.

## When to prefer this

Use this endpoint when you need a broad, market-level view of the clinical pipeline for a specific disease — ideal for biotech investors assessing competitive crowding, pharma strategists sizing an indication, or analysts benchmarking pipeline activity. Prefer this over deeper single-trial or company-specific endpoints when the goal is landscape-level intelligence rather than granular trial design details.

## Known failure modes

- Unknown or misspelled disease name returns empty result or error
- Very rare diseases may return very low trial counts or no data
- Service unavailable returns HTTP 402 or 5xx if payment fails
- Ambiguous disease names (e.g. 'cancer') may require more specificity
- Rate limiting or quota exceeded if called too frequently

## How this service works

Clinical trial pipeline scan for any disease — all active Phase 2/3 trials with trial counts, sponsor landscape, geographic distribution, mechanism breakdown and pipeline density, across 400,000+ trials worldwide. For biotech-investing and pharma agents.

## Output

Returns structured data including total count of active Phase 2/3 trials for the queried disease, a breakdown of sponsor organizations (biotech, big pharma, academic), geographic distribution of trial sites across regions, and a pipeline density score or summary — all drawn from a database of 400,000+ trials.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string"
      },
      "phase": {
       "type": "string"
      },
      "status": {
       "type": "string"
      },
      "condition": {
       "type": "string"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "query_summary": {
   "condition": "Non-Small Cell Lung Cancer",
   "status_filter": "RECRUITING,ACTIVE_NOT_RECRUITING",
   "phases_searched": [
    "PHASE2",
    "PHASE3"
   ]
  },
  "pipeline_totals": {
   "phase2_count": 156,
   "phase3_count": 89,
   "total_active": 245
  },
  "phase3_highlights": [
   {
    "nctId": "NCT05116748",
    "title": "Pembrolizumab + Carboplatin vs SOC in NSCLC",
    "status": "RECRUITING",
    "sponsor": "Merck",
    "countries": [
     "United States",
     "Germany",
     "Japan",
     "South Korea"
    ],
    "primaryCompletion": "2026-03"
   }
  ],
  "sponsor_landscape": {
   "academic_sponsors": "ECOG-ACRIN, Alliance, NCI leading academic cooperative groups",
   "emerging_biotechs": [
    "Turning Point Therapeutics",
    "Blueprint Medicines",
    "Mirati Therapeutics"
   ],
   "top_industry_sponsors": [
    "Roche/Genentech (18 trials)",
    "Bristol-Myers Squibb (14)",
    "AstraZeneca (13)",
    "Merck (12)",
    "Pfizer (11)"
   ]
  },
  "mechanism_breakdown": {
   "adc": 18,
   "other": 81,
   "bispecific": 12,
   "targeted_therapy": 41,
   "chemo_combinations": 31,
   "io_checkpoint_inhibitors": 62
  },
  "pipeline_assessment": "Extremely crowded pipeline — PD-1/L1 space saturated. ADCs and bispecifics represent highest differentiation potential. KRAS G12C targeted therapies emerging as new standard.",
  "approved_drugs_context": "NSCLC has 30+ FDA-approved agents. Pipeline is additive rather than disruptive in most cases.",
  "geographic_distribution": {
   "asia_pct": 22,
   "other_pct": 5,
   "europe_pct": 28,
   "us_trials_pct": 45,
   "most_active_countries": [
    "United States",
    "China",
    "Germany",
    "South Korea",
    "Japan"
   ]
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/clinicalintelpulse-pipeline-scan-88bf5074/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clinicalintelpulse.vercel.app](https://www.zero.xyz/host/clinicalintelpulse.vercel.app/llms.txt)