# ClinicalIntelPulse Trial Brief

> ClinicalIntelPulse Trial Brief is a paid API for AI agents from clinicalintelpulse.vercel.app, paid per call via x402, $0.1/call, status unknown (last checked 2026-09-15).

Returns a comprehensive deep-dive on a specific clinical trial by NCT ID, including full study design, endpoints, enrollment status, sponsor, eligibility criteria, and publications.

## Facts

- Endpoint: GET https://clinicalintelpulse.vercel.app/api/clinical/trial-brief
- Price: $0.1/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/clinicalintelpulse-trial-brief-af03bfc8
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_ZRWtCCsvtvczJvw4v3bIa

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability clinicalintelpulse-trial-brief-af03bfc8
```

Example prompt: Pull the full trial brief for NCT04280705 — I need the study design, primary and secondary endpoints, current enrollment status, sponsor, recruitment criteria, and any linked publications.

## When to prefer this

Use this endpoint when you need a comprehensive, structured profile of a single known clinical trial identified by its NCT ID. Ideal for biotech analysts, research agents, and due diligence workflows that require complete trial design, endpoint definitions, eligibility logic, and publication history in one call, rather than browsing ClinicalTrials.gov manually or searching across disease areas.

## Known failure modes

- Invalid or malformed NCT ID returns a 404 or error response
- Trial not found in the database returns empty or null result
- Payment of 0.1 USDC not processed via x402 returns 402 Payment Required
- Older or withdrawn trials may have incomplete endpoint or publication data
- Rate limiting or service unavailability returns 5xx error

## How this service works

Clinical trial deep dive by NCT ID — full trial design, primary/secondary endpoints, enrollment status and countries, sponsor, recruitment criteria, outcomes and publications for any ClinicalTrials.gov study. For research and biotech agents.

## Output

A structured deep-dive report on the specified clinical trial including: full study design (phase, arms, interventions, blinding), primary and secondary endpoints, current enrollment status (recruiting, completed, terminated, etc.), sponsor and collaborators, inclusion/exclusion recruitment criteria, and associated publications or results citations.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string"
      },
      "nct_id": {
       "type": "string"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "design": {
   "arms": [
    "Tiragolumab + Atezolizumab + Carboplatin/Paclitaxel",
    "Placebo + Atezolizumab + Carboplatin/Paclitaxel"
   ],
   "masking": "Double-Blind",
   "allocation": "Randomized",
   "study_type": "INTERVENTIONAL",
   "primary_purpose": "Treatment"
  },
  "endpoints": {
   "primary": [
    "Progression-Free Survival (PFS)",
    "Overall Survival (OS)"
   ],
   "secondary": [
    "Objective Response Rate",
    "Duration of Response",
    "Safety/Tolerability"
   ]
  },
  "enrollment": {
   "actual": 534,
   "planned": 534,
   "countries": [
    "United States",
    "Spain",
    "Germany",
    "Japan",
    "Australia"
   ]
  },
  "interventions": [
   {
    "name": "Tiragolumab",
    "role": "Anti-TIGIT immune checkpoint inhibitor",
    "type": "DRUG"
   }
  ],
  "query_summary": {
   "nct_id": "NCT04368728",
   "retrieved_from": "ClinicalTrials.gov v2 API"
  },
  "trial_identity": {
   "phase": "PHASE3",
   "title": "A Study of Tiragolumab in Combination With Atezolizumab and Chemotherapy Versus Placebo in Untreated Locally Advanced Unresectable or Metastatic NSCLC (SKYSCRAPER-01)",
   "status": "COMPLETED",
   "sponsor": "Hoffmann-La Roche",
   "start_date": "2019-06",
   "primary_completion": "2022-12"
  },
  "outcome_summary": "SKYSCRAPER-01 failed to meet primary PFS endpoint (HR 0.93). Significant negative readout for anti-TIGIT in NSCLC.",
  "regulatory_implications": "Setback for Roche tiragolumab program. Broader TIGIT class facing headwinds."
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/clinicalintelpulse-trial-brief-af03bfc8/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clinicalintelpulse.vercel.app](https://www.zero.xyz/host/clinicalintelpulse.vercel.app/llms.txt)