# CNS-IPI Calculator (Schmitz 2016) — DLBCL CNS Relapse Risk

> CNS-IPI Calculator (Schmitz 2016) — DLBCL CNS Relapse Risk is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).

Calculates the CNS-IPI score (0–6) for DLBCL patients to estimate CNS relapse risk after R-CHOP, based on five standard IPI factors plus kidney/adrenal involvement.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/cns_ipi
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/cns-ipi-calculator-schmitz-2016-dlbcl-cns-relapse-risk-fa68759c
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_aoT877YTYtmSKRDkQMJVz

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability cns-ipi-calculator-schmitz-2016-dlbcl-cns-relapse-risk-fa68759c
```

Example prompt: Calculate the Schmitz 2016 CNS-IPI score for a 67-year-old DLBCL patient with ECOG 2, LDH above normal, Ann Arbor stage IV, more than one extranodal site, and kidney involvement — what's the risk category?

## When to prefer this

Use this endpoint when you need to deterministically compute the Schmitz 2016 CNS-IPI score for a DLBCL patient — specifically when you need the six-factor variant (standard IPI factors plus kidney/adrenal involvement) rather than the original Shipp 1993 IPI, the R-IPI, or the NCCN-IPI. Prefer this over generic clinical calculators when you need a reproducible, published-formula result with no LLM hallucination risk. It is not a substitute for clinical staging, imaging, or LP ordering decisions.

## Known failure modes

- Missing required query parameters (age, ecog, ldh_gt_uln, stage_iii_or_iv, extranodal_gt_1, kidney_or_adrenal) returns a 400 error
- Age outside 18–120 range returns a validation error
- Non-integer values for age or ecog return a schema error
- ECOG value outside 0–4 range may return an error
- Payment failure or missing x402 header results in a 402 Payment Required response

## How this service works

Schmitz 2016 CNS-IPI: Shipp IPI factors (age >60, ECOG ≥2, LDH > ULN, Ann Arbor III or IV, extranodal sites >1) plus kidney and/or adrenal involvement; 1 point each, max 6. Low 0–1, intermediate 2–3, high 4–6. CNS relapse risk after R-CHOP in DLBCL. Deterministic published score; not a CNS prophylaxis or LP order; not NCCN-IPI; not R-IPI; not a DLBCL diagnosis. magent does not stage lymphoma or image kidneys.

## Output

Returns a CNS-IPI total score (integer 0–6), individual factor contributions, and the corresponding risk category (low: 0–1, intermediate: 2–3, high: 4–6), reflecting the Schmitz 2016 published algorithm for CNS relapse risk estimation in DLBCL after R-CHOP.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "age",
      "ecog",
      "ldh_gt_uln",
      "stage_iii_or_iv",
      "extranodal_gt_1",
      "kidney_or_adrenal"
     ],
     "properties": {
      "age": {
       "type": "integer",
       "description": "Age in years (18-120). Age >60 scores 1 (Schmitz 2016). Age 60 is the ≤60 arm and scores 0."
      },
      "ecog": {
       "type": "integer",
       "description": "ECOG performance status 0-4 as assigned by the caller (Schmitz 2016). ≥2 scores 1. magent does not assign ECOG."
      },
      "ldh_gt_uln": {
       "type": "boolean",
       "description": "Serum LDH above the upper limit of normal as assigned by the caller (Schmitz 2016). true scores 1. magent does not assay LDH."
      },
      "extranodal_gt_1": {
       "type": "boolean",
       "description": "More than one extranodal site as assigned by the caller (Schmitz 2016). true scores 1. magent does not count extranodal sites."
      },
      "stage_iii_or_iv": {
       "type": "boolean",
       "description": "Ann Arbor stage III or IV as assigned by the caller (Schmitz 2016). true scores 1. magent does not stage lymphoma."
      },
      "kidney_or_adrenal": {
       "type": "boolean",
       "description": "Kidney and/or adrenal involvement as assigned by the caller (Schmitz 2016). true scores 1. magent does not image kidneys."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/cns-ipi-calculator-schmitz-2016-dlbcl-cns-relapse-risk-fa68759c/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)