# CryptoETFSentinel PDUFA Upcoming Catalysts

> CryptoETFSentinel PDUFA Upcoming Catalysts is a paid API for AI agents from pdufa.cryptoetfsentinel.com, paid per call via x402, $0.02/call, status down (last checked 2026-09-15).

Returns upcoming FDA PDUFA drug approval decision dates for US-listed biotech companies, sourced from primary SEC 8-K/6-K filings

## Facts

- Endpoint: GET https://pdufa.cryptoetfsentinel.com/v1/catalysts/upcoming
- Price: $0.02/call
- Payment: x402
- Status: down
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/cryptoetfsentinel-pdufa-upcoming-catalysts-4590c08d
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_wGEblDw9MXDDDk01LbTWH

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability cryptoetfsentinel-pdufa-upcoming-catalysts-4590c08d
```

Example prompt: Show me all upcoming FDA PDUFA decision dates for US-listed biotechs within the next 90 days — limit results to 50 — I want to see which drug approval binary events are coming up soonest based on SEC filing data.

## When to prefer this

Use this endpoint when you need PDUFA dates derived from primary regulatory filings (SEC 8-K/6-K) rather than community-curated calendars, offering verifiable accuracy with a backtested median 1-day error. Prefer this over general biotech news APIs when you need structured, machine-readable catalyst data with quantified accuracy guarantees and a configurable time horizon.

## Known failure modes

- No catalysts found within the specified date window — returns empty data array
- Invalid within_days or limit parameter values outside allowed ranges (1-365, 1-500) — validation error
- Payment not completed via x402 protocol — 402 Payment Required response
- Rate limit or upstream SEC data unavailability — 5xx error with error message in response body
- Stale data if SEC filings have not been recently indexed — check meta object for freshness

## How this service works

Upcoming FDA drug-approval (PDUFA) decision dates for US-listed biotechs — a forward catalyst calendar extracted from primary SEC 8-K/6-K filings, every date grounded in a verbatim filing quote and cited to its EDGAR accession. The difference from other catalyst feeds: each date is scored against the actual FDA decision, so accuracy is a public, auditable track record (median 1-day error) — verify it free at GET /v1/accuracy before you pay.

## Output

An array of upcoming FDA PDUFA catalyst events for publicly traded biotechs, each including the company, drug/indication, expected FDA decision date sourced from SEC 8-K/6-K filings, plus metadata on result count and any errors. Dates are backtested with median 1-day accuracy against actual FDA decisions.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "limit": {
       "type": "integer",
       "maximum": 500,
       "minimum": 1,
       "description": "Maximum number of catalysts to return (1-500; default 200)."
      },
      "within_days": {
       "type": "integer",
       "maximum": 365,
       "minimum": 1,
       "description": "Only return catalysts whose PDUFA date falls within this many days from today (1-365; default 365)."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object",
     "properties": {
      "data": {
       "type": "array",
       "items": {
        "type": "object"
       },
       "description": "One row per upcoming catalyst: drug_name, company, ticker, indication, pdufa_date, stage, confidence, source_url."
      },
      "meta": {
       "type": "object",
       "description": "Result metadata, e.g. total count."
      },
      "error": {
       "type": [
        "string",
        "null"
       ],
       "description": "Error string, or null."
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/cryptoetfsentinel-pdufa-upcoming-catalysts-4590c08d/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pdufa.cryptoetfsentinel.com](https://www.zero.xyz/host/pdufa.cryptoetfsentinel.com/llms.txt)