# FDA FAERS Drug Safety Signal Detection (PRR)

> FDA FAERS Drug Safety Signal Detection (PRR) is a paid API for AI agents from www.x402pulse.dev, paid per call via x402, $0.0875/call, status unknown (last checked 2026-10-12).

Detects adverse drug reaction signals from FDA FAERS data using Proportional Reporting Ratio (PRR) and chi-square with Evans criteria to identify side effects reported disproportionately often for a specific drug.

## Facts

- Endpoint: GET https://www.x402pulse.dev/v1/health/safety-signals?utm_source=zero.xyz
- Price: $0.0875/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-12
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/fda-faers-drug-safety-signal-detection-prr-37a375f5
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_bg59gGuEuLH3qYSkGKzx-

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability fda-faers-drug-safety-signal-detection-prr-37a375f5
```

Example prompt: Can you pull the FDA FAERS safety signals for metformin — I want to see which side effects are reported disproportionately often compared to all other drugs, using the PRR and Evans criteria.

## When to prefer this

Choose this endpoint when you need a quantitative, statistically grounded adverse event signal analysis for a specific drug using the industry-standard PRR and Evans criteria methodology applied to the FDA FAERS database. Prefer it over raw label lookups (which give approved warnings) when you want empirical post-market reporting patterns. It is not a replacement for clinical judgment or FDA-approved labeling.

## Known failure modes

- Drug name not found in FAERS database — returns empty or no-signal response
- Misspelled or unrecognized drug name — may return no results
- Drug with very few FAERS reports — insufficient data for reliable PRR computation
- Rate limiting if fair-use thresholds exceeded
- Network timeout on FAERS data retrieval

## How this service works

Drug safety signal detection (pharmacovigilance) from FDA FAERS: side effects reported disproportionately often with a drug versus all other drugs, using the proportional reporting ratio (PRR) and chi-square with standard Evans criteria. A statistical prompt for study, not evidence of harm. Not medical advice.

## Output

Returns a list of adverse event terms (MedDRA or similar) that are reported disproportionately often with the queried drug versus all other drugs in FDA FAERS, along with their PRR values, chi-square statistics, and whether each signal meets the standard Evans criteria thresholds. Includes a disclaimer that results are statistical signals for study, not evidence of causality or medical advice.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "drug"
     ],
     "properties": {
      "drug": {
       "type": "string",
       "description": "Drug brand or generic name"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "data": {
   "drug": "atorvastatin",
   "method": "Proportional reporting ratio vs. all other drugs in FAERS (Evans criteria).",
   "signals": [
    {
     "prr": 14.2,
     "signal": true,
     "reports": 2020,
     "reaction": "rhabdomyolysis",
     "chiSquare": 2650.4
    }
   ],
   "drugReports": 52000,
   "signalCount": 3,
   "reactionsChecked": 25
  },
  "cached": false
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/fda-faers-drug-safety-signal-detection-prr-37a375f5/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from www.x402pulse.dev](https://www.zero.xyz/host/www.x402pulse.dev/llms.txt)