# FDA Orange Book Drug Application Lookup

> FDA Orange Book Drug Application Lookup is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Retrieves FDA-approved drug applications from openFDA by active ingredient, including application numbers, sponsors, brand names, dosage forms, marketing status, and Orange Book TE codes.

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/fda-orange-book?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/fda-orange-book-drug-application-lookup-6ef0a0a5
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_EulYiEO6E8Ur_Cdzbtx8P

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability fda-orange-book-drug-application-lookup-6ef0a0a5
```

Example prompt: Can you look up FDA-approved drug applications for metformin and show me the sponsors, brand names, dosage forms, and Orange Book TE codes — give me up to 8 results?

## When to prefer this

Choose this endpoint when you need structured FDA regulatory data — application numbers, sponsors, TE codes — tied to a specific active ingredient. It draws directly from openFDA's official Drugs@FDA dataset, making it authoritative for Orange Book lookups, generic equivalence research, and pharmaceutical compliance checks. Prefer it over general web search when you need machine-readable, structured drug approval data with TE codes.

## Known failure modes

- Missing or invalid 'ingredient' parameter returns an error
- Ingredient string outside 2–60 characters or containing non-letter characters is rejected
- Active ingredient not found in FDA database returns empty results
- Max parameter outside 1–10 range may be ignored or cause an error
- openFDA upstream API downtime may cause failed or delayed responses

## How this service works

FDA Drugs@FDA approved applications (openFDA) by active ingredient: application number, sponsor, brand names, dosage form, marketing status and Orange Book therapeutic equivalence (TE) code. Up to 10 applications per call.

## Output

Returns up to 10 FDA drug application records per call, each containing the application number (NDA/ANDA), sponsor name, brand name(s), dosage form, marketing status, and Orange Book therapeutic equivalence (TE) code for the queried active ingredient.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "ingredient"
     ],
     "properties": {
      "max": {
       "type": "string",
       "description": "How many applications, 1 to 10 (default 5)"
      },
      "ingredient": {
       "type": "string",
       "description": "Active ingredient name, letters and spaces, 2 to 60 characters"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/fda-orange-book-drug-application-lookup-6ef0a0a5/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)