# FDA Regulatory Catalyst Calendar — Market-Wide (Multi-Issuer)

> FDA Regulatory Catalyst Calendar — Market-Wide (Multi-Issuer) is a paid API for AI agents from api.agentstools.dev, paid per call via x402, $0.05/call, status unknown (last checked 2026-09-15).

Returns upcoming FDA regulatory events (PDUFA dates, AdComm meetings, CRLs, priority reviews) across many biotech issuers at once, each grounded in a cited SEC 8-K/6-K filing quote with EDGAR accession and URL.

## Facts

- Endpoint: GET https://api.agentstools.dev/catalyst/upcoming
- Price: $0.05/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/fda-regulatory-catalyst-calendar-market-wide-multi-issuer-8cebda14
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_7nnWadFGGGmPWRIhk_Lva

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability fda-regulatory-catalyst-calendar-market-wide-multi-issuer-8cebda14
```

Example prompt: Pull me the next 15 upcoming FDA regulatory catalysts across biotech — PDUFA dates and advisory committee meetings only — over the next 180 days, with the SEC filing quotes and EDGAR links backing each one.

## When to prefer this

Choose this endpoint when you need a market-wide sweep of FDA catalysts across many biotech issuers in a single call rather than querying one issuer at a time. It is ideal for constructing a catalyst calendar, screening the biotech universe for binary events, or building a risk-aware portfolio view. The companion single-issuer endpoint is better when you need exhaustive detail on one specific company.

## Known failure modes

- No events found in the specified forward window — returns empty list
- limit out of range (must be 1–15) — returns 400 validation error
- forward_days out of range (must be 1–730) — returns 400 validation error
- Invalid event_type enum value — returns 400 validation error
- Payment not attached or insufficient — returns 402 Payment Required
- Upstream SEC EDGAR ingestion lag may mean very recently filed events are absent

## How this service works

Market-wide upcoming FDA regulatory catalysts across recent SEC 8-K and 6-K filings in a forward window. Get PDUFA dates, advisory committee meetings and other regulatory events for many biotech issuers at once, each grounded in a filing quote and cited to its accession and EDGAR URL. Bounded fan-out.

## Output

A list of up to 15 upcoming FDA regulatory events across multiple biotech issuers, each including the event type (pdufa, adcomm, crl, priority_review, pdufa_extension), expected date, issuer name, a verbatim quote from the underlying SEC 8-K or 6-K filing, the accession number, and a direct EDGAR URL for verification.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [],
     "properties": {
      "limit": {
       "type": "integer",
       "maximum": 15,
       "minimum": 1,
       "description": "Max events to return, default 15"
      },
      "event_types": {
       "type": "array",
       "items": {
        "enum": [
         "pdufa",
         "adcomm",
         "crl",
         "priority_review",
         "pdufa_extension"
        ],
        "type": "string"
       },
       "description": "Optional filter of regulatory event types to include (default all)"
      },
      "forward_days": {
       "type": "integer",
       "maximum": 730,
       "minimum": 1,
       "description": "Forward window in days, default 365"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/fda-regulatory-catalyst-calendar-market-wide-multi-issuer-8cebda14/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.agentstools.dev](https://www.zero.xyz/host/api.agentstools.dev/llms.txt)