# fittings FDA Orange Book Therapeutic Equivalence

> fittings FDA Orange Book Therapeutic Equivalence is a paid API for AI agents from fittings.sh, paid per call via x402, $0.00692/call, status unknown (last checked 2026-09-14).

Returns FDA therapeutic equivalence (TE) ratings, reference drug status, application type, sponsor, and marketing status for a drug by name or application number.

## Facts

- Endpoint: GET https://fittings.sh/v1/orangebook/therapeutic-equivalence
- Price: $0.00692/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/fittings-fda-orange-book-therapeutic-equivalence-82bb1b2c
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap___Ad4VaRm1NS16CnDRK3o

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability fittings-fda-orange-book-therapeutic-equivalence-82bb1b2c
```

Example prompt: Can you look up the FDA therapeutic equivalence ratings for atorvastatin — show me the TE codes, which product is the reference listed drug, and who the sponsors are?

## When to prefer this

Use this endpoint when you need FDA Orange Book therapeutic equivalence data including TE codes, RLD/RS designation, sponsor, application type, and marketing status for a drug. Prefer this over general drug databases when the specific FDA TE classification is required — e.g. for generic substitution decisions, formulary management, or regulatory compliance checks. Note: patent and exclusivity data are not included, so use a different source for those needs.

## Known failure modes

- Drug name not found in Orange Book — returns empty result set
- Ambiguous drug name matching multiple compounds — may return unintended products
- Invalid application number format — may return no results or an error
- Limit parameter out of range (outside 1–25) — may be clamped or rejected
- Patent and exclusivity data is explicitly excluded — requests for that data will yield no results

## How this service works

FDA therapeutic equivalence codes for a drug: the TE rating and what it means, whether each product is the reference listed drug or reference standard, plus application type, sponsor and marketing status. Patent and exclusivity listings are not included.

## Output

A list of drug products (up to the requested limit) each containing: the FDA TE rating code (e.g. AB, BX), a plain-English explanation of what that code means, whether the product is designated as the reference listed drug (RLD) or reference standard (RS), the FDA application type (NDA, ANDA, etc.), the application number, the sponsor/manufacturer name, and the current marketing status.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [],
     "properties": {
      "drug": {
       "type": "string",
       "description": "Brand or generic drug name, e.g. atorvastatin"
      },
      "limit": {
       "type": "number",
       "description": "Applications to return, 1-25, default 10"
      },
      "application": {
       "type": "string",
       "description": "FDA application number instead of a name, e.g. NDA020702 or ANDA217279"
      }
     }
    }
   },
   "additionalProperties": false
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/fittings-fda-orange-book-therapeutic-equivalence-82bb1b2c/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from fittings.sh](https://www.zero.xyz/host/fittings.sh/llms.txt)