# Greipp 2005 ISS Myeloma Staging Calculator

> Greipp 2005 ISS Myeloma Staging Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Computes the International Staging System (ISS) stage (I, II, or III) for multiple myeloma from serum beta-2 microglobulin and albumin values per Greipp 2005 criteria.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/myeloma_iss
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/greipp-2005-iss-myeloma-staging-calculator-75a72bcd
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_dPJssc6zbfGtPWMvH3NbO

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability greipp-2005-iss-myeloma-staging-calculator-75a72bcd
```

Example prompt: What is the ISS myeloma stage for a patient with a serum beta-2 microglobulin of 4.2 mg/L and a serum albumin of 3.8 g/dL using the Greipp 2005 criteria?

## When to prefer this

Use this endpoint when you need to apply the classic Greipp 2005 ISS criteria (Stage I/II/III) to lab values for multiple myeloma staging. Prefer this over R-ISS calculators when LDH and cytogenetics data are unavailable or not required. Do not use for trauma ISS scoring, myeloma diagnosis, or treatment selection.

## Known failure modes

- Missing required beta2_microglobulin_mg_l parameter returns an error
- Providing both albumin_g_l and albumin_g_dl simultaneously is rejected
- Values outside accepted ranges (e.g. beta-2 microglobulin outside 0.2–40 mg/L, albumin outside 1–6 g/dL) may return validation errors
- No albumin provided when beta-2 microglobulin is below 5.5 and staging requires it may produce ambiguous output

## How this service works

Greipp 2005 International Staging System for multiple myeloma. Stage I: serum beta-2 microglobulin <3.5 mg/L and albumin >=3.5 g/dL. Stage III: beta-2 microglobulin >=5.5 mg/L. Stage II: neither I nor III. Returns iss_stage 1/2/3. Not a myeloma diagnosis or treatment choice; not R-ISS (no LDH, no cytogenetics); not trauma ISS. magent does not assay beta-2 microglobulin or albumin.

## Output

Returns iss_stage as an integer (1, 2, or 3) representing the ISS stage per Greipp 2005: Stage I (beta-2 microglobulin <3.5 mg/L and albumin ≥3.5 g/dL), Stage III (beta-2 microglobulin ≥5.5 mg/L), and Stage II (neither I nor III).

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "beta2_microglobulin_mg_l"
     ],
     "properties": {
      "albumin_g_l": {
       "type": "number",
       "description": "Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both."
      },
      "albumin_g_dl": {
       "type": "number",
       "description": "Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. Greipp 2005 stages use g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5."
      },
      "beta2_microglobulin_mg_l": {
       "type": "number",
       "description": "Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 Sβ2M. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "path": "/api/calc/myeloma_iss",
  "count": 2,
  "items": [
   {
    "formula": "myeloma_iss",
    "citation": {
     "id": "greipp-2005",
     "doi": "10.1200/JCO.2005.04.242",
     "pmid": "15809451",
     "title": "International staging system for multiple myeloma",
     "source": "J Clin Oncol. 2005;23(15):3412-3420",
     "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"
    },
    "iss_stage": 1,
    "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
    "albumin_g_dl": 4,
    "iss_stage_label": "I",
    "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
    "beta2_microglobulin_mg_l": 2
   },
   {
    "formula": "myeloma_iss",
    "citation": {
     "id": "greipp-2005",
     "doi": "10.1200/JCO.2005.04.242",
     "pmid": "15809451",
     "title": "International staging system for multiple myeloma",
     "source": "J Clin Oncol. 2005;23(15):3412-3420",
     "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"
    },
    "iss_stage": 1,
    "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
    "albumin_g_dl": 4,
    "iss_stage_label": "I",
    "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
    "beta2_microglobulin_mg_l": 2
   }
  ]
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/greipp-2005-iss-myeloma-staging-calculator-75a72bcd/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)