# ClinVar Genetic Variants Lookup

> ClinVar Genetic Variants Lookup is a paid API for AI agents from health.memoryapi.org, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15, last successful call 2026-07-19).

Returns pathogenic and benign ClinVar genetic variants for a given gene, including clinical significance and associated conditions.

## Facts

- Endpoint: GET https://health.memoryapi.org/x402/health/variants
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Last successful call: 2026-07-19
- Success rate: 100% of calls made through Zero
- Activations on Zero: 20
- Tags: x402
- Canonical page: https://www.zero.xyz/c/health-memoryapi-org-19e817e5
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_OmwBeoOWkJtJMO55Bq1lF

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability health-memoryapi-org-19e817e5
```

Example prompt: Can you pull all pathogenic and likely pathogenic ClinVar variants for the BRCA2 gene, along with the associated conditions they're linked to?

## When to prefer this

Use this endpoint when you need structured, curated clinical variant data from ClinVar — particularly when you need to know the pathogenicity classification and disease associations for variants in a specific gene. Prefer this over raw genome databases when clinical significance context is required.

## Known failure modes

- Unknown or misspelled gene symbol returns empty result set
- Gene with no ClinVar entries returns empty array
- Invalid filter parameters may return 400 error
- Rate limiting or payment failure (x402) may block access
- Network timeout for genes with very large variant catalogs

## How this service works

ClinVar genetic variants — pathogenic/benign variants for any gene with clinical significance and conditions.

## Output

A list of genetic variants from ClinVar for the queried gene, each annotated with pathogenicity classification (e.g. pathogenic, benign, likely pathogenic), clinical significance details, and associated medical conditions or diseases.

## Example request

```json
{
 "limit": 10,
 "country": "USA",
 "indicator": "WHOSIS_000001"
}
```

## Request schema (JSON Schema)

```json
{
 "properties": {
  "input": {
   "properties": {
    "method": {
     "type": "string",
     "enum": [
      "GET"
     ]
    }
   },
   "required": [
    "method"
   ]
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "example": {
  "gene": "BRCA1",
  "count": 10,
  "success": true,
  "variants": [
   {
    "title": "NM_007294.4(BRCA1):c.68_69del (p.Glu23fs)",
    "conditions": [
     "Hereditary breast ovarian cancer syndrome"
    ],
    "variation_id": "12345",
    "clinical_significance": "Pathogenic"
   }
  ],
  "significance": "pathogenic"
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/health-memoryapi-org-19e817e5/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from health.memoryapi.org](https://www.zero.xyz/host/health.memoryapi.org/llms.txt)