# Human Protein Atlas — Gene/Protein Expression by Tissue and Brain Region

> Human Protein Atlas — Gene/Protein Expression by Tissue and Brain Region is a paid API for AI agents from health.memoryapi.org, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Returns gene and protein expression data across human tissues and brain regions from the Human Protein Atlas database.

## Facts

- Endpoint: GET https://health.memoryapi.org/x402/health/protein
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/health-memoryapi-org-e4e30b6d
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_aOk4ngxPLPYeeBjshHaa0

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability health-memoryapi-org-e4e30b6d
```

Example prompt: Look up the Human Protein Atlas expression data for the gene APOE and tell me which tissues and brain regions show the highest protein expression levels.

## When to prefer this

Use this endpoint when you need structured, curated protein or gene expression data across human tissues and brain regions, particularly for biomedical research, drug target analysis, or understanding where a specific gene is active in the body. Prefer this over general genomics APIs when you specifically need tissue-level or brain-region-level protein expression from the Human Protein Atlas.

## Known failure modes

- Unknown gene or protein name returns empty or error response
- Misspelled gene symbol returns no results
- Rate limiting or payment failure returns 402 status
- Unsupported tissue or brain region filter returns empty results
- Gene exists but has no expression data in the atlas

## How this service works

Health and biomedical data API powered by x402 micropayments. Access NIH grants, WHO health statistics, ClinVar genetic variants, and Human Protein Atlas expression data.

## Output

Returns protein and gene expression data for the queried gene or protein across human tissues and brain regions, including expression scores, tissue names, and regional specificity data sourced from the Human Protein Atlas.

## Example request

```json
{
 "gene": "APOE",
 "type": "expression"
}
```

## Request schema (JSON Schema)

```json
{
 "properties": {
  "input": {
   "required": [
    "method"
   ],
   "properties": {
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "example": {
  "gene": "BRCA1",
  "success": true,
  "proteins": [
   {
    "gene": "BRCA1",
    "ensembl": "ENSG00000012048",
    "uniprot": "P38398",
    "top_tissues": [
     {
      "value": 12.4,
      "tissue": "breast"
     }
    ]
   }
  ],
  "results_count": 1
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/health-memoryapi-org-e4e30b6d/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from health.memoryapi.org](https://www.zero.xyz/host/health.memoryapi.org/llms.txt)