# Hegele 2025 NAFCS Score Calculator (FCS Likelihood) > Hegele 2025 NAFCS Score Calculator (FCS Likelihood) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15). Computes the Hegele 2025 North American Familial Chylomicronemia Syndrome (NAFCS) clinical score to estimate likelihood of classical FCS based on age, lipid values, BMI, and clinical history ## Facts - Endpoint: GET https://api.magentlab.com/api/calc/nafcs - Price: $0.005/call - Payment: x402 - Status: unknown - Last checked: 2026-09-15 - Activations on Zero: 0 - Tags: x402 - Canonical page: https://www.zero.xyz/c/hegele-2025-nafcs-score-calculator-fcs-likelihood-a6228e1e - Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_Dn970GvRWBbXqZD4Q1pCT Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently. ## How to call it through Zero Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`): ```sh zero fetch --capability hegele-2025-nafcs-score-calculator-fcs-likelihood-a6228e1e ``` Example prompt: Score this patient for familial chylomicronemia syndrome using the Hegele 2025 NAFCS criteria: she's 34 years old, her HTG started before age 10, BMI is below threshold, she has a history of pancreatitis, secondary factors are present, fasting TGs are 1200 mg/dL, TG/TC ratio is 9, and apo B is 0.7 g/L — what's her NAFCS score and does she meet the definite FCS threshold? ## When to prefer this Use this endpoint when you need to apply the Hegele 2025 NAFCS clinical scoring table to estimate the likelihood of familial chylomicronemia syndrome (FCS/LPL deficiency) in a patient. Choose this over generic hypertriglyceridemia tools when the specific Hegele 2025 North American criteria (Table 3 point system) are required. Not appropriate for Simon Broome or Dutch FH scoring, genetic testing interpretation, or patients under 1 year of age. ## Known failure modes - Missing required parameters (age_years, htg_onset_before_age_10, bmi_below_threshold, abdominal_history, secondary_factors_present) returns a 400 error - Providing both tg_mg_dl and tg_mmol_l simultaneously causes a validation error - TG values outside range (mg/dL 440–20000 or mmol/L 5–226) rejected - Age below 1 year not supported by the scoring model - Providing both apo_b_g_l and apo_b_mg_dl simultaneously causes a validation error - Payment failure (x402) results in 402 response requiring USDC payment ## How this service works Hegele 2025 NAFCS. Table 3 points from age or early HTG onset, BMI, abdominal pain or pancreatitis, secondary factors, fasting TG >880 mg/dL or >10 mmol/L, TG/TC >8 (mg/dL) or >3.5 (mmol/L), and apo B <1.0 g/L, plus published interactions. Max 100. ≥60 definite classical FCS; ≥45 very likely. Not a diagnosis or genetic test. Not Simon Broome or Dutch FH. magent does not examine the patient or assay lipids. Not a medical device. ## Output Returns an integer NAFCS score from 0–100 with a per-criterion point breakdown. Scores ≥60 indicate definite classical FCS; scores ≥45 indicate very likely FCS. The result is an arithmetic clinical scoring aid, not a diagnosis, genetic test, or output from a medical device. ## Request schema (JSON Schema) ```json { "type": "object", "$schema": "https://json-schema.org/draft/2020-12/schema", "required": [ "input" ], "properties": { "input": { "type": "object", "required": [ "type", "method" ], "properties": { "type": { "type": "string", "const": "http" }, "method": { "enum": [ "GET", "HEAD", "DELETE" ], "type": "string" }, "headers": { "type": "object", "additionalProperties": { "type": "string" } }, "queryParams": { "type": "object", "required": [ "age_years", "htg_onset_before_age_10", "bmi_below_threshold", "abdominal_history", "secondary_factors_present" ], "properties": { "tg_mg_dl": { "type": "number", "description": "Caller-assigned fasting triglycerides in mg/dL (440-20000) representing all readings used in the score (Hegele 2025 Table 1: last 3 labs in adults, last 2 in children). All readings >880 score 13. Provide exactly one of tg_mg_dl or tg_mmol_l. magent does not assay lipids." }, "age_years": { "type": "integer", "description": "Current age in whole years (1-120). Hegele 2025 Table 3: ages 1-9 score child_htg 12; ages ≥10 score early_htg_onset 12 only when htg_onset_before_age_10 is true. The score does not provide a value for infants <1 year. magent does not examine the patient." }, "apo_b_g_l": { "type": "number", "description": "Apolipoprotein B in g/L (0.1-3.0). <1.0 scores 12 (Hegele 2025 Table 3). Provide exactly one of apo_b_g_l or apo_b_mg_dl. 1.0 g/L = 100 mg/dL in the paper. magent does not assay apo B." }, "tg_mmol_l": { "type": "number", "description": "Caller-assigned fasting triglycerides in mmol/L (5-226). All readings >10 score 13. Provide exactly one of tg_mg_dl or tg_mmol_l. magent does not assay lipids." }, "apo_b_mg_dl": { "type": "number", "description": "Apolipoprotein B in mg/dL (10-300). <100 scores 12. Provide exactly one of apo_b_g_l or apo_b_mg_dl. magent does not assay apo B." }, "abdominal_history": { "enum": [ "none", "abdominal_pain", "pancreatitis" ], "type": "string", "description": "Caller-assigned chylomicronemia-related abdominal history (Hegele 2025 Table 3): none (0), abdominal_pain = recurrent abdominal pain without pancreatitis (9), pancreatitis = history of … (truncated) ``` ## More - Live health (JSON, refreshed every minute): https://www.zero.xyz/c/hegele-2025-nafcs-score-calculator-fcs-likelihood-a6228e1e/health.json - [Zero catalog index](https://www.zero.xyz/llms.txt) - [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)