# HerbaPulse Drug-Herb Interaction Checker

> HerbaPulse Drug-Herb Interaction Checker is a paid API for AI agents from herbapulse.vercel.app, paid per call via x402, $0.1/call, status unknown (last checked 2026-09-13).

Checks for interactions between pharmaceutical drugs and herbal supplements using PubMed-grounded evidence

## Facts

- Endpoint: GET https://herbapulse.vercel.app/api/herba/interaction
- Price: $0.1/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-13
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/herbapulse-drug-herb-interaction-checker-173be632
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_sLAabVVf001aPEhm0pf5t

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability herbapulse-drug-herb-interaction-checker-173be632
```

Example prompt: Can you check whether taking St. John's Wort alongside sertraline (an SSRI antidepressant) is safe — I want to see the evidence base, the interaction severity, and any mechanism details?

## When to prefer this

Use this endpoint when you need evidence-grounded herb-drug interaction data, especially when covering traditional medicine systems like Ayurveda or TCM alongside conventional pharmaceuticals. Prefer this over generic drug interaction databases when the query involves botanical supplements, herbal remedies, or plant-based treatments.

## Known failure modes

- Unknown herb or drug name returns empty or null interaction data
- Rare herb-drug combinations may lack PubMed evidence, returning low-confidence results
- Misspelled herb or drug names may fail to match database entries
- Non-English queries may have reduced accuracy depending on translation quality
- Rate limiting or payment failures via x402 micropayment protocol

## How this service works

Global herbal medicine and botanical intelligence API. PubMed-grounded herb profiles, drug-herb interaction checker, traditional medicine system guides (Ayurveda, TCM, Amazonian, African), herbal remedy builder, skin/cosmetic botanical analysis, cannabis strain intelligence, herbal practitioner finder, and ingredient safety checker. Covers Ayurvedic, TCM, Western herbalism, Indigenous, and integrative medicine traditions. iHerb, Mountain Rose Herbs, Gaia Herbs, Herb Pharm, and Leafly (cannabis) affiliate links included. All endpoints support any language via ?lang=. Pricing: $0.08–$0.15 USDC/call via x402 micropayment.

## Output

Returns a structured report of known drug-herb interactions including severity rating (e.g. mild/moderate/severe), the pharmacological mechanism, PubMed-grounded evidence citations, and safety recommendations for the queried herb-drug combination.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "required": [
  "herb"
 ],
 "properties": {
  "drug": {
   "type": "string",
   "description": "drug"
  },
  "herb": {
   "type": "string",
   "description": "herb"
  },
  "lang": {
   "type": "string",
   "description": "lang"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {}
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/herbapulse-drug-herb-interaction-checker-173be632/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from herbapulse.vercel.app](https://www.zero.xyz/host/herbapulse.vercel.app/llms.txt)