# HFA-ICOS BCR-ABL Cardiovascular Risk Classifier (Lyon 2020) > HFA-ICOS BCR-ABL Cardiovascular Risk Classifier (Lyon 2020) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14). Calculates the Lyon 2020 HFA-ICOS baseline cardiovascular risk category (very_high, high, medium, or low) prior to BCR-ABL-targeting TKI therapy for CML, based on published very-high, high, and medium risk factor criteria. ## Facts - Endpoint: GET https://api.magentlab.com/api/calc/hfa_icos_bcr_abl - Price: $0.005/call - Payment: x402 - Status: unknown - Last checked: 2026-09-14 - Activations on Zero: 0 - Tags: x402 - Canonical page: https://www.zero.xyz/c/hfa-icos-bcr-abl-cardiovascular-risk-classifier-lyon-2020-ece269fb - Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_fevAPodWcelLEI3B9xxoS Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently. ## How to call it through Zero Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`): ```sh zero fetch --capability hfa-icos-bcr-abl-cardiovascular-risk-classifier-lyon-2020-ece269fb ``` Example prompt: Using the Lyon 2020 HFA-ICOS framework for BCR-ABL TKI therapy, classify the cardiovascular risk for a 68-year-old male patient with a QTc of 455 ms, LVEF of 58%, hypertension, diabetes, hyperlipidemia, and a BMI over 30 — no prior arterial vascular disease, no heart failure, no arrhythmia, and no venous thromboembolism; his 10-year CVD risk is above 20%. ## When to prefer this Use this endpoint when you need a structured, rule-based Lyon 2020 HFA-ICOS cardiovascular risk class for a CML patient being evaluated for BCR-ABL TKI therapy (second- or third-generation, e.g. dasatinib, nilotinib, ponatinib). Prefer it over generic cardiovascular risk calculators (SCORE2, Framingham, PCE) because it applies the specific cardio-oncology factor table published for BCR-ABL inhibitors rather than general population risk models. It is appropriate when the caller has already assessed threshold values like eGFR, HbA1c, and 10-year CVD risk externally and needs the categorical risk class for documentation or clinical decision support workflows. ## Known failure modes - Missing required parameters (e.g. age_years, sex, qtc_ms, lvef_percent) returns a 400-level validation error - QTc value outside the accepted 300–700 ms range is rejected - age_years outside 18–100 range is rejected - Boolean fields passed as strings rather than true/false may fail schema validation - Caller-assigned threshold fields (e.g. cvd_10y_risk_gt_20, ckd, diabetes) not assessed by the API — incorrect caller assignment produces incorrect risk class - Payment failure (x402) if USDC not provided correctly returns a 402 response ## How this service works Lyon 2020 HFA-ICOS baseline cardiovascular risk before second- or third-generation multi-targeted kinase inhibitors for CML targeting BCR-ABL. Class is very_high, high, medium, or low from published very-high and high factors plus Medium 1/2 points (0–1 low, 2–4 medium, ≥5 high). Caller assigns the 10-year CVD >20% threshold; magent does not compute that score. Not a medical device or treatment order. ## Output Returns one of four risk classes — very_high, high, medium, or low — based on the Lyon 2020 HFA-ICOS BCR-ABL TKI cardiovascular risk table. The response reflects which very-high, high, or medium-point factors (Medium 1 and Medium 2) drove the classification, per the published scoring logic (0–1 = low, 2–4 = medium, ≥5 = high). Not a medical device output or treatment recommendation. ## Request schema (JSON Schema) ```json { "type": "object", "$schema": "https://json-schema.org/draft/2020-12/schema", "required": [ "input" ], "properties": { "input": { "type": "object", "required": [ "type", "method" ], "properties": { "type": { "type": "string", "const": "http" }, "method": { "enum": [ "GET", "HEAD", "DELETE" ], "type": "string" }, "headers": { "type": "object", "additionalProperties": { "type": "string" } }, "queryParams": { "type": "object", "required": [ "age_years", "sex", "lvef_percent", "qtc_ms", "arterial_vascular_disease", "arterial_thrombosis_with_tki", "heart_failure_or_lvsd", "bcr_abl_tki_mediated_lvsd", "abpi_le_0_9", "pulmonary_arterial_hypertension", "cvd_10y_risk_gt_20", "current_or_significant_smoker", "venous_thromboembolism", "arrhythmia", "hypertension", "diabetes", "hyperlipidemia", "ckd", "family_history_thrombophilia", "obesity" ], "properties": { "ckd": { "type": "boolean", "description": "Caller-assigned chronic kidney disease (paper: eGFR <60 mL/min/1.73 m²). Medium 1. magent does not compute eGFR." }, "sex": { "type": "string", "description": "Sex male or female. Selects the borderline QTc Medium 2 window (men 450≤QTc<480; women 460≤QTc<480). magent does not read an ECG." }, "qtc_ms": { "type": "number", "description": "QTc in milliseconds (300-700). ≥480 is High. Borderline Medium 2 is men 450≤QTc<480 and women 460≤QTc<480. magent does not measure QTc." }, "obesity": { "type": "boolean", "description": "Caller-assigned obesity (paper: BMI >30 kg/m²). Medium 1. magent does not compute BMI." }, "diabetes": { "type": "boolean", "description": "Caller-assigned diabetes (paper: HbA1c >7.0% or >53 mmol/mol, or on treatment). Medium 1. magent does not diagnose diabetes." }, "age_years": { "type": "integer", "description": "Age in years (integer 18-100). Lyon 2020 BCR-ABL table: ≥75 High; 65-74 Medium 2; 60-64 Medium 1 (paper row Age ≥60 years under the higher bands); <60 none. Bands do not stack. magent does not examine the patient." }, "arrhythmia": { "type": "boolean", "description": "Caller-assigned arrhythmia (paper: atria … (truncated) ``` ## More - Live health (JSON, refreshed every minute): https://www.zero.xyz/c/hfa-icos-bcr-abl-cardiovascular-risk-classifier-lyon-2020-ece269fb/health.json - [Zero catalog index](https://www.zero.xyz/llms.txt) - [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)