# HFA-ICOS RAF/MEK Inhibitor Baseline Cardiovascular Risk Calculator > HFA-ICOS RAF/MEK Inhibitor Baseline Cardiovascular Risk Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14). Classifies a patient's baseline cardiovascular risk (Very High / High / Medium / Low) before starting RAF and MEK inhibitor therapy, using the Lyon 2020 HFA-ICOS framework. ## Facts - Endpoint: GET https://api.magentlab.com/api/calc/hfa_icos_raf_mek - Price: $0.005/call - Payment: x402 - Status: unknown - Last checked: 2026-09-14 - Activations on Zero: 0 - Tags: x402 - Canonical page: https://www.zero.xyz/c/hfa-icos-raf-mek-inhibitor-baseline-cardiovascular-risk-calculator-cc8ee00d - Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_vQ4jBXkBkDeDW0j6bqOGZ Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently. ## How to call it through Zero Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`): ```sh zero fetch --capability hfa-icos-raf-mek-inhibitor-baseline-cardiovascular-risk-calculator-cc8ee00d ``` Example prompt: My patient is 68 years old with an LVEF of 52%, a history of prior anthracycline use, hypertension, and diabetes — no heart failure, MI, CABG, angina, valvular disease, arrhythmia, elevated troponin, elevated BNP, prior chest radiation, CKD, significant smoking, or obesity. What is their HFA-ICOS baseline cardiovascular risk category before we start a RAF and MEK inhibitor combination? ## When to prefer this Use this endpoint when you need to apply the specific Lyon 2020 HFA-ICOS cardiotoxicity risk classification framework for patients being considered for RAF and/or MEK inhibitor combination therapy. It implements the exact risk table with Very High / High / Medium / Low tiers and medium-point counting. Prefer this over generic cardiovascular risk calculators (e.g., Framingham, SCORE) when the clinical question is specifically about cardiotoxicity risk before targeted cancer therapy, not general population ASCVD risk. ## Known failure modes - Missing required boolean parameters returns a validation error - Age outside 18–100 range is rejected - LVEF values outside expected range may not be handled - Ambiguous or non-boolean inputs for flag fields cause schema errors - Network timeout or upstream server error returns a 5xx response - Payment not included or insufficient returns a 402 Payment Required error ## How this service works Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors. Very high if heart failure or cardiomyopathy; High if MI/CABG, stable angina, severe valvular disease, prior anthracycline, or ≥5 medium points; Medium if 2-4 medium points; Low if 0-1. Age ≥65 is Medium 1 only. LVEF 50-54 is Medium 2; this table has no printed LVEF <50 High row. Expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / ≥20%. Not a treatment order. ## Output Returns a categorical cardiovascular risk classification (Very High, High, Medium, or Low) based on the Lyon 2020 HFA-ICOS RAF/MEK table, along with the count of medium-risk points accumulated and a corresponding expert-opinion cardiotoxicity probability band (<2%, 2–9%, 10–19%, or ≥20%). This is an informational risk stratification output, not a treatment order. ## Request schema (JSON Schema) ```json { "type": "object", "$schema": "https://json-schema.org/draft/2020-12/schema", "required": [ "input" ], "properties": { "input": { "type": "object", "required": [ "type", "method" ], "properties": { "type": { "type": "string", "const": "http" }, "method": { "enum": [ "GET", "HEAD", "DELETE" ], "type": "string" }, "headers": { "type": "object", "additionalProperties": { "type": "string" } }, "queryParams": { "type": "object", "required": [ "age_years", "lvef_percent", "heart_failure_or_cardiomyopathy", "mi_or_cabg", "stable_angina", "severe_valvular_heart_disease", "prior_anthracycline", "elevated_troponin", "elevated_bnp", "hypertension", "prior_left_chest_or_mediastinal_rt", "arrhythmia", "diabetes", "ckd", "current_or_significant_smoker", "obesity" ], "properties": { "ckd": { "type": "boolean", "description": "Chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute eGFR." }, "obesity": { "type": "boolean", "description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute BMI." }, "diabetes": { "type": "boolean", "description": "Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not assay haemoglobin A1c." }, "age_years": { "type": "integer", "description": "Age in whole years (18-100). Lyon 2020 RAF-MEK table: age ≥65 is Medium 1. There is no High age band on this table. magent does not read an identity document." }, "arrhythmia": { "type": "boolean", "description": "Atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation as assigned by the caller (Lyon 2020 RAF-MEK table footnote). true is Medium 1. magent does not read an ECG." }, "mi_or_cabg": { "type": "boolean", "description": "Myocardial infarction or CABG as assigned by the caller (Lyon 2020 RAF-MEK table). true is High." }, "elevated_bnp": { "type": "boolean", "d … (truncated) ``` ## More - Live health (JSON, refreshed every minute): https://www.zero.xyz/c/hfa-icos-raf-mek-inhibitor-baseline-cardiovascular-risk-calculator-cc8ee00d/health.json - [Zero catalog index](https://www.zero.xyz/llms.txt) - [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)