# Invoket Medication Interactions Checker

> Invoket Medication Interactions Checker is a paid API for AI agents from api.invoket.com, paid per call via x402, $0.01/call, status unknown (last checked 2026-09-14).

Checks drug-drug interactions between medications identified by French CIS code, US NDC, INN/DCI substance name, or ANSM class, returning provenance-backed results from official sources.

## Facts

- Endpoint: POST https://api.invoket.com/medication/interactions
- Price: $0.01/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/invoket-medication-interactions-checker-11906c9b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_pDZcseH3osy08jh3O_60Y

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability invoket-medication-interactions-checker-11906c9b -d '<json body>'
```

Example prompt: Before I take these three medications together — metformin 500mg, lisinopril, and ibuprofen — can you check whether any dangerous drug interactions exist between them?

## When to prefer this

Choose this endpoint when you need authoritative, provenance-backed drug interaction data sourced from official French (ANSM) and international pharmacological databases, especially when working with French CIS codes or needing a FR-US NDC bridge. Prefer this over general LLM-generated drug advice when clinical reliability and traceable provenance are required for pre-action safety checks in healthcare or pharmacy workflows.

## Known failure modes

- 400 if fewer than 2 or more than 50 items are submitted
- 400 if an item has multiple keys or a malformed key
- 400 if item keys are not one of: cis, ndc, dci, class
- Unresolvable NDC codes may result in no interaction evaluation for that item
- 200 with empty interactions array if no interactions are known (still billed)

## How this service works

Check drug-drug interactions against the authoritative French ANSM thesaurus before your agent acts on a prescription or an order: post 2+ medications (CIS code, US NDC, INN/DCI substance or ANSM class) and get every published interaction between them - constraint level (contre_indication, association_deconseillee, precaution_emploi, a_prendre_en_compte), management advice and mechanism exactly as published by ANSM, plus honest coverage of anything that could not be compared. US drugs join via the INN substance bridge. No account, no key, pay per call.

## Output

A JSON object containing an interactions array listing all detected drug-drug interaction pairs among the submitted items, each with interaction details, severity level, and provenance from official sources. An empty interactions array means no known interactions were found between any evaluated pairs — this is itself a billable, meaningful answer.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "required": [
  "items"
 ],
 "properties": {
  "items": {
   "type": "array",
   "description": "2 to 50 items, each with EXACTLY one key: cis (8-digit French CIS), ndc (US product NDC, evaluated once resolved to INN substances - the FR-US bridge), dci (INN/DCI substance name), class (ANSM class label). Fewer than 2 items, more than 50 (every pair is evaluated, so the cost is quadratic - the 400 states the limit), several keys on one item or a malformed key = 400; a well-formed list with no interaction = 200 with interactions:[] (billed - no known interaction between the evaluated pairs IS the answer)"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "object"
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/invoket-medication-interactions-checker-11906c9b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.invoket.com](https://www.zero.xyz/host/api.invoket.com/llms.txt)