# IPS-E Score Calculator (Condoluci 2020) for Early-Stage CLL

> IPS-E Score Calculator (Condoluci 2020) for Early-Stage CLL is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).

Computes the Condoluci 2020 IPS-E time-to-first-treatment prognostic score (0–3) for asymptomatic early-stage chronic lymphocytic leukemia using three caller-assigned binary/numeric inputs.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/ips_e
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ips-e-score-calculator-condoluci-2020-for-early-stage-cll-953612b1
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_n4KJEtdaCGtqRj-ME38E-

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ips-e-score-calculator-condoluci-2020-for-early-stage-cll-953612b1
```

Example prompt: Calculate the IPS-E score for an early-stage CLL patient who has unmutated IGHV, an absolute lymphocyte count of 20 ×10^9/L, and palpable lymph nodes — tell me their risk group.

## When to prefer this

Use this endpoint when you need a fast, standardized Condoluci 2020 IPS-E score for asymptomatic early-stage CLL and already have the three required clinical values (IGHV mutation status, ALC, palpable lymph nodes) pre-assessed. This is specifically for prognostic time-to-first-treatment stratification in early CLL, not for CLL-IPI, Rai staging, or Binet staging. Prefer this over a general LLM computation when you need a reproducible, published-algorithm result.

## Known failure modes

- Missing required query parameters (ighv_unmutated, alc_k_ul, palpable_lymph_nodes) returns a 400 error
- ALC value outside the accepted range (0.1–500 ×10^9/L) may return validation error
- Payment not provided or invalid x402 payment header causes 402 response
- Caller misclassifying clinical inputs (IGHV status, ALC, node exam) before submission — the API trusts caller-assigned values without verification

## How this service works

Condoluci 2020 IPS-E for asymptomatic early-stage chronic lymphocytic leukemia: unmutated IGHV 1, ALC >15 ×10^9/L 1, palpable lymph nodes 1; max 3. Low 0, intermediate 1, high 2–3. Time-to-first-treatment score, not a treatment start order; not CLL-IPI, Rai, or Binet. magent does not assay IGHV, count lymphocytes, or palpate nodes.

## Output

Returns an IPS-E integer score from 0 to 3, where 0 = low risk, 1 = intermediate risk, and 2–3 = high risk for time to first treatment in asymptomatic early-stage CLL, based on the three Condoluci 2020 criteria.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "ighv_unmutated",
      "alc_k_ul",
      "palpable_lymph_nodes"
     ],
     "properties": {
      "alc_k_ul": {
       "type": "number",
       "description": "Absolute lymphocyte count in ×10^9/L (0.1-500). >15 scores 1 (Condoluci 2020 IPS-E). 15.0 is the ≤15 arm and scores 0. magent does not count lymphocytes."
      },
      "ighv_unmutated": {
       "type": "boolean",
       "description": "Unmutated IGHV as assigned by the caller (Condoluci 2020 IPS-E). true scores 1. magent does not sequence IGHV."
      },
      "palpable_lymph_nodes": {
       "type": "boolean",
       "description": "Palpable lymph nodes as assigned by the caller (Condoluci 2020 IPS-E). true scores 1. magent does not palpate lymph nodes."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ips-e-score-calculator-condoluci-2020-for-early-stage-cll-953612b1/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)