# ISTH Overt DIC Score (Taylor 2001)

> ISTH Overt DIC Score (Taylor 2001) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Calculates the ISTH Scientific and Standardisation Committee overt disseminated intravascular coagulation (DIC) score from four laboratory values, returning a total score and compatibility verdict.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/isth_dic
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/isth-overt-dic-score-taylor-2001-68edf732
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_668G737qo6vVbFoCSeTGD

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability isth-overt-dic-score-taylor-2001-68edf732
```

Example prompt: Run the ISTH overt DIC score for a patient with platelets of 62 ×10^9/L, PT prolongation of 4.5 seconds above ULN, fibrinogen 0.8 g/L, and a strong fibrin-related marker result.

## When to prefer this

Use this endpoint when you need a standardized, reproducible ISTH overt DIC score per the Taylor 2001 algorithm for adult patients, particularly in ICU, hematology, or obstetric workflows. Prefer this over manual calculation to eliminate arithmetic errors and ensure correct boundary handling (e.g. exactly 50 platelets scores 1, not 0). Do not use for the non-overt serial DIC score or for pediatric-specific DIC scoring systems.

## Known failure modes

- Missing required parameters (platelets, fibrin_related_marker, or pt_prolongation_sec) returns a validation error
- Providing both fibrinogen_g_l and fibrinogen_mg_dl simultaneously returns an error (XOR fields)
- Out-of-range values (e.g. platelets >2000 or PT prolongation >30) may be rejected
- Invalid fibrin_related_marker enum value (must be none, moderate, or strong) returns an error
- Network or payment failure results in no score returned

## How this service works

Taylor 2001 ISTH SSC overt DIC (four lab items; max 8). Platelets >=100=0, 50-<100=1, <50=2. fibrin_related_marker none/moderate/strong = 0/2/3 (caller-assigned; magent does not grade D-dimer). PT sec above ULN <3=0, >=3 and <6=1, >=6=2. Fibrinogen >=1.0 g/L=0, <1.0=1 (XOR g/L or mg/dL÷100). Band <5 not compatible with overt DIC; >=5 compatible. Not a diagnosis. Not the non-overt serial score.

## Output

Returns the total ISTH overt DIC score (0–8), individual sub-scores for each of the four laboratory components, and a binary interpretation: score ≥5 is compatible with overt DIC, score <5 is not compatible. Does not issue a clinical diagnosis.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "platelets_10e9_l",
      "fibrin_related_marker",
      "pt_prolongation_sec"
     ],
     "properties": {
      "fibrinogen_g_l": {
       "type": "number",
       "description": "Fibrinogen in g/L (0.1-10). Provide this or fibrinogen_mg_dl, not both. >=1.0 scores 0; <1.0 scores 1. 1.0 scores 0 (Taylor 2001)."
      },
      "fibrinogen_mg_dl": {
       "type": "number",
       "description": "Fibrinogen in mg/dL (10-1000). Converted as g/L = mg/dL / 100. Provide this or fibrinogen_g_l, not both."
      },
      "platelets_10e9_l": {
       "type": "number",
       "description": "Platelet count ×10^9/L (1-2000). >=100 scores 0; 50 to <100 scores 1; <50 scores 2. 100 scores 0; 50 scores 1; 49 scores 2 (Taylor 2001)."
      },
      "pt_prolongation_sec": {
       "type": "number",
       "description": "Prothrombin time prolongation in seconds above the laboratory ULN (0-30). <3 scores 0; >=3 and <6 scores 1; >=6 scores 2. 3.0 and 5.9 score 1; 6.0 scores 2; 2.9 scores 0 (Taylor 2001 table gaps filled at 3 and 6)."
      },
      "fibrin_related_marker": {
       "enum": [
        "none",
        "moderate",
        "strong"
       ],
       "type": "string",
       "description": "Caller-assigned ISTH fibrin-related marker (Taylor 2001). none scores 0; moderate scores 2; strong scores 3. magent does not grade D-dimer assays."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "path": "/api/calc/isth_dic",
  "count": 2,
  "items": [
   {
    "score": 0,
    "formula": "isth_dic",
    "citation": {
     "id": "taylor-2001",
     "doi": "10.1055/s-0037-1616068",
     "pmid": "11816725",
     "title": "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation",
     "source": "Thromb Haemost. 2001;86(5):1327-1330",
     "authors": "Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M"
    },
    "max_score": 8,
    "components": [
     {
      "value": 180,
      "factor": "platelets",
      "points": 0,
      "present": false
     },
     {
      "value": "none",
      "factor": "fibrin_related_marker",
      "points": 0,
      "present": false
     },
     {
      "value": 1,
      "factor": "pt_prolongation",
      "points": 0,
      "present": false
     },
     {
      "value": 2.5,
      "factor": "fibrinogen",
      "points": 0,
      "present": false
     }
    ],
    "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
    "isth_dic_band": "<5",
    "fibrinogen_g_l": 2.5,
    "platelets_10e9_l": 180,
    "formula_expression": "ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5",
    "pt_prolongation_sec": 1,
    "fibrin_related_marker": "none"
   },
   {
    "score": 0,
    "formula": "isth_dic",
    "citation": {
     "id": "taylor-2001",
     "doi": "10.1055/s-0037-1616068",
     "pmid": "11816725",
     "title": "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation",
     "source": "Thromb Haemost. 2001;86(5):1327-1330",
     "authors": "Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M"
    },
    "max_score": 8,
    "components": [
     {
      "value": 180,
      "factor": "platelets",
      "points": 0,
      "present": false
     },
     {
      "value": "none",
      "factor": "fibrin_related_marker",
      "points": 0,
      "present": false
     },
     {
      "value": 1,
      "factor": "pt_prolongation",
      "points": 0,
      "present": false
     },
     {
      "value": 2.5,
      "factor": "fibrinogen",
      "points": 
… (truncated)
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/isth-overt-dic-score-taylor-2001-68edf732/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
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