# IWG-2 Typical Alzheimer's Disease Criteria Calculator (Dubois 2014)

> IWG-2 Typical Alzheimer's Disease Criteria Calculator (Dubois 2014) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Applies the Dubois 2014 IWG-2 criteria to determine whether a patient meets the definition of typical Alzheimer's disease based on caller-supplied clinical flags.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/iwg2_ad
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/iwg-2-typical-alzheimer-s-disease-criteria-calculator-dubois-2014-05879d17
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_wdKQN6Jw3k0X5S2Krp4Nl

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability iwg-2-typical-alzheimer-s-disease-criteria-calculator-dubois-2014-05879d17
```

Example prompt: Check if this patient meets IWG-2 typical Alzheimer's disease criteria: they have early hippocampal-type episodic memory impairment, positive CSF Abeta1-42 plus tau results, negative amyloid PET, no autosomal dominant mutation, and no better explanation for the symptoms.

## When to prefer this

Use this endpoint when you need to programmatically apply the specific Dubois 2014 IWG-2 criteria for typical Alzheimer's disease — not NIA-AA ATN, not NINCDS-ADRDA, not DSM. Ideal for research pipelines, clinical trial screening workflows, or EHR automation where a clinician or upstream system has already assigned the five binary clinical flags and you need a rule-based IWG-2 classification without manual lookup.

## Known failure modes

- Missing required query parameters (early_episodic_memory, csf_abeta_and_tau, amyloid_pet, autosomal_dominant_mutation, no_better_explanation) returns an error
- Non-boolean values for any flag cause a validation error
- Atypical AD phenotypes are outside scope and will not be correctly classified
- Endpoint cannot generate or verify the underlying clinical data — garbage-in, garbage-out if flags are incorrectly assigned by the caller

## How this service works

Dubois 2014 IWG-2 typical AD research criteria. typical_ad iff early hippocampal-type episodic memory, no better explanation, and in-vivo AD pathology (CSF Abeta1-42 plus T-tau or P-tau, amyloid PET, or a PSEN1/PSEN2/APP mutation). Typical AD only; not atypical phenotypes. Not NINCDS-ADRDA, not NIA-AA ATN, not DSM. magent does not examine the patient, assay CSF, or read PET. Not a diagnosis or medical device.

## Output

Returns a boolean classification indicating whether the patient meets the Dubois 2014 IWG-2 definition of typical Alzheimer's disease (typical_ad: true/false), based on the five caller-supplied flags: early hippocampal-type episodic memory impairment, CSF Abeta/tau pathology, amyloid PET positivity, autosomal dominant mutation, and absence of a better explanation.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "early_episodic_memory",
      "csf_abeta_and_tau",
      "amyloid_pet",
      "autosomal_dominant_mutation",
      "no_better_explanation"
     ],
     "properties": {
      "amyloid_pet": {
       "type": "boolean",
       "description": "Increased tracer retention on amyloid PET, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not read PET."
      },
      "csf_abeta_and_tau": {
       "type": "boolean",
       "description": "Decreased Aβ1-42 together with increased T-tau or P-tau in CSF, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not assay CSF."
      },
      "early_episodic_memory": {
       "type": "boolean",
       "description": "Early and significant episodic memory impairment of the hippocampal type (IWG-2 specific phenotype for typical AD), as assigned by the caller. true or false. magent does not examine the patient."
      },
      "no_better_explanation": {
       "type": "boolean",
       "description": "Exclusion of other disorders that could account for the phenotype, as assigned by the caller (Dubois 2014 IWG-2). true or false. magent does not examine the patient."
      },
      "autosomal_dominant_mutation": {
       "type": "boolean",
       "description": "Proven AD autosomal-dominant mutation in PSEN1, PSEN2, or APP, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not sequence genes."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/iwg-2-typical-alzheimer-s-disease-criteria-calculator-dubois-2014-05879d17/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)