# KEGG Human Pathway Genes Lookup

> KEGG Human Pathway Genes Lookup is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Returns pathway metadata (name, class, description) and up to 100 genes (KEGG gene ID, symbol, description) for a given human KEGG pathway number via the KEGG REST API.

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/kegg-pathway-genes?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/kegg-human-pathway-genes-lookup-0041369c
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_SxEegkBY0KAXtX_NF1mz4

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability kegg-human-pathway-genes-lookup-0041369c
```

Example prompt: What genes are in KEGG human pathway 05200 (Pathways in cancer)? Give me up to 50 genes with their KEGG IDs and descriptions.

## When to prefer this

Choose this endpoint when you need structured gene membership data for a specific human KEGG pathway by number, including gene IDs, symbols, and descriptions alongside pathway metadata. It is ideal for bioinformatics workflows, pathway enrichment analysis, literature research, or building gene-disease association tools. Prefer it over manual KEGG website lookups or bulk downloads when you need programmatic, per-call access to pathway gene lists with pay-per-use pricing.

## Known failure modes

- Invalid or non-existent pathway number returns an error or empty gene list
- Non-human pathway numbers (e.g. mouse pathways) may not be supported
- max parameter out of range (>100 or <1) may return an error or default to 20
- KEGG REST API downtime causes request failure
- Pathway with fewer genes than requested max returns only available genes

## How this service works

KEGG human pathway (KEGG REST, flat file): pathway name, class, description and the genes in it (KEGG gene ID, symbol and description). Give a human pathway number such as 05200. Up to 100 genes per call.

## Output

Returns the KEGG pathway's name, class, and description, followed by a list of up to 100 member genes each with their KEGG gene ID, official gene symbol, and textual description — sourced from the KEGG REST flat-file API for human pathways.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "pathway"
     ],
     "properties": {
      "max": {
       "type": "string",
       "description": "How many genes, 1 to 100 (default 20)"
      },
      "pathway": {
       "type": "string",
       "description": "Five-digit human KEGG pathway number, e.g. 05200 (Pathways in cancer)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/kegg-human-pathway-genes-lookup-0041369c/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)