# Longevity Pulse Epigenetic Clock Intelligence

> Longevity Pulse Epigenetic Clock Intelligence is a paid API for AI agents from longevitypulse.vercel.app, paid per call via x402, $0.2/call, status unknown (last checked 2026-09-13).

Explains biological vs chronological age, the major epigenetic clocks (GrimAge, DunedinPACE, Horvath, PhenoAge), how to get tested, and evidence-based interventions to reverse biological aging.

## Facts

- Endpoint: GET https://longevitypulse.vercel.app/api/longevity/epigenetic-clock
- Price: $0.2/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-13
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/longevity-pulse-epigenetic-clock-intelligence-2d05b3d7
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_5gg_98OvkBMT9su6k4fGN

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability longevity-pulse-epigenetic-clock-intelligence-2d05b3d7
```

Example prompt: Can you explain the difference between GrimAge, DunedinPACE, Horvath, and PhenoAge epigenetic clocks, tell me which one is most predictive of mortality, and give me the best evidence-backed ways I can actually lower my biological age?

## When to prefer this

Choose this endpoint when a user wants to understand epigenetic clocks, biological age testing, or evidence-based strategies to reverse aging. Prefer this over generic health endpoints when the query specifically involves epigenetic aging science, clock methodologies (GrimAge, DunedinPACE, Horvath, PhenoAge), or the distinction between biological and chronological age.

## Known failure modes

- Payment not provided or invalid — 402 response requiring x402 USDC payment
- Network or server timeout on Vercel deployment — 503 or 504 response
- Rate limiting if called in rapid succession — 429 response
- Malformed request parameters — 400 response

## How this service works

Epigenetic clock / biological age intelligence (GrimAge, DunedinPACE, Horvath, PhenoAge) for longevity and health agents. Explains biological vs chronological age, how to test your biological age, and evidence-based ways to slow or reverse it. Health intelligence, not medical advice.

## Output

Returns a comprehensive intelligence briefing covering: definitions and mechanisms of major epigenetic clocks (GrimAge, DunedinPACE, Horvath, PhenoAge), how biological age differs from chronological age, available testing options and how to access them, and evidence-graded interventions (lifestyle, diet, supplements, drugs) shown to reduce biological age in clinical or research settings.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string",
       "description": "en | es | fr | de | ja | zh | ko | pt | ar | hi (default: en)"
      },
      "topic": {
       "type": "string",
       "description": "What to explore — e.g. \"GrimAge\" | \"DunedinPACE\" | \"biological age overview\" | \"how to reverse biological aging\" | \"epigenetic reprogramming\" | \"how to test biological age\" | \"what accelerates epigenetic aging\""
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "topic": "DunedinPACE",
  "key_clocks_explained": [
   {
    "name": "DunedinPACE",
    "developer": "Dan Belsky et al., Duke University, 2022",
    "what_it_measures": "Pace of aging — how fast you are aging RIGHT NOW (not just where you are)",
    "what_makes_it_unique": "Measures rate of change rather than point-in-time — more sensitive to interventions"
   }
  ],
  "biological_age_vs_chronological_age": {
   "concept": "Biological age measures how fast your cells are aging — not how many years you've been alive",
   "predictive_power": "A 5-year older biological age is associated with 35% higher mortality risk",
   "magnitude_of_difference": "People of the same chronological age can differ by 20+ years in biological age"
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/longevity-pulse-epigenetic-clock-intelligence-2d05b3d7/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from longevitypulse.vercel.app](https://www.zero.xyz/host/longevitypulse.vercel.app/llms.txt)