# LongevityPulse DNA Variant Interpreter

> LongevityPulse DNA Variant Interpreter is a paid API for AI agents from longevitypulse.vercel.app, paid per call via x402, $0.2/call, status unknown (last checked 2026-09-13).

Interprets consumer DNA test variants (rsIDs, gene names like APOE-e4, MTHFR-C677T, FOXO3) with honest effect sizes, actionability tiers, and myth-flags for longevity-relevant SNPs

## Facts

- Endpoint: GET https://longevitypulse.vercel.app/api/longevity/dna
- Price: $0.2/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-13
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/longevitypulse-dna-variant-interpreter-8ebb640b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_hb99If_TYRnFWpOlrv3iC

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability longevitypulse-dna-variant-interpreter-8ebb640b
```

Example prompt: I just got my 23andMe results and I want to know what APOE-e4 and MTHFR-C677T actually mean for my longevity — give me the real effect sizes and tell me if MTHFR is as scary as the supplement industry claims.

## When to prefer this

Choose this endpoint when a user has specific consumer DNA test results (23andMe, AncestryDNA) and wants honest, calibrated interpretation of longevity-relevant variants — particularly when they need myth-busting (e.g. MTHFR panic), real effect sizes rather than fear-based framing, and explicit flags for overstated claims. Prefer this over generic genetics databases when actionability tiers and longevity context matter, and when the user needs nuanced probabilistic language rather than binary risk labels.

## Known failure modes

- Unrecognized variant or rsID returns recognized:false with no effect size data
- Variant exists but has insufficient evidence — returns a plain statement that evidence is lacking rather than speculative content
- Malformed gene/rsID input may result in no match
- Rate limiting or payment failure at the x402 layer may prevent the call from completing

## How this service works

DNA variant interpretation for longevity agents. Reads consumer-test genes/rsIDs (23andMe, AncestryDNA) e.g. APOE-e4, MTHFR-C677T, FOXO3. Honest effect sizes (not fear), actionability tiers, myth-flags overstated claims like MTHFR panic, and says plainly when a variant lacks real evidence. Not medical advice.

## Output

A JSON array of variant results, each containing: the gene name, input identifier, whether it was recognized, a plain-English effect size with honest odds ratios and context, an actionability tier (e.g. 'well-replicated'), the resolved rsID, and optionally a myth_flag object explaining if and why the variant's risks are commonly overstated or mythologized in popular health culture.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string",
       "description": "en|es|fr|de|ja|zh|ko|pt|ar|hi (default en)"
      },
      "variants": {
       "type": "string",
       "description": "Comma-separated gene/variant IDs or rsIDs from a consumer DNA test, e.g. APOE-e4,MTHFR-C677T,FOXO3 (up to 8, required)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "results": [
   {
    "gene": "APOE",
    "input": "APOE-e4",
    "recognized": true,
    "effect_size": "One ε4 copy: ~2-3x Alzheimer's odds ratio vs ε3/ε3; two copies: ~8-12x — one of the largest common-variant effect sizes in human genetics, still a probabilistic shift, not a diagnosis",
    "actionability_tier": "well-replicated",
    "resolved_identifier": "rs429358 (APOE ε4 tagging SNP)"
   },
   {
    "input": "MTHFR-C677T",
    "myth_flag": {
     "the_myth": "Marketed as a serious \"detox\"/methylation defect requiring supplement protocols",
     "is_commonly_overstated_or_mythologized": true
    }
   }
  ],
  "variants_requested": [
   "APOE-e4",
   "MTHFR-C677T",
   "FOXO3"
  ]
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/longevitypulse-dna-variant-interpreter-8ebb640b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from longevitypulse.vercel.app](https://www.zero.xyz/host/longevitypulse.vercel.app/llms.txt)