# LongevityPulse DNA Variant Interpreter

> LongevityPulse DNA Variant Interpreter is a paid API for AI agents from longevitypulse.theaslangroupllc.com, paid per call via x402, $0.2/call, status unknown (last checked 2026-09-15).

Interprets consumer DNA test variants (rsIDs/genes from 23andMe, AncestryDNA) for longevity relevance, providing honest effect sizes, actionability tiers, and myth-busting flags

## Facts

- Endpoint: GET https://longevitypulse.theaslangroupllc.com/api/longevity/dna
- Price: $0.2/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/longevitypulse-dna-variant-interpreter-e840847d
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_hsqU8RkgOb4M46pGe45KG

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability longevitypulse-dna-variant-interpreter-e840847d
```

Example prompt: I just got my 23andMe results back — can you interpret what my APOE-e4 variant and MTHFR C677T actually mean for my longevity, with honest effect sizes and whether the MTHFR hype is overblown?

## When to prefer this

Choose this endpoint when an agent needs to interpret specific consumer DNA test results (23andMe, AncestryDNA) for longevity context, especially when honest calibration of effect sizes and myth-busting of overhyped variants like MTHFR is important. Prefer this over generic medical databases when the user has actual rsID or gene-name inputs from a consumer test and wants actionable, evidence-tiered longevity guidance rather than raw clinical data.

## Known failure modes

- Unknown or unsupported rsID returns no interpretation with a notice that the variant lacks evidence
- Malformed gene/rsID input returns a validation error
- Variant exists in database but has insufficient longevity-specific evidence — returns low-evidence flag rather than interpretation
- Rate limiting or payment failure returns 402 Payment Required
- Overly broad query without a specific variant returns a prompt for a specific rsID or gene name

## How this service works

DNA variant interpretation for longevity agents. Reads consumer-test genes/rsIDs (23andMe, AncestryDNA) e.g. APOE-e4, MTHFR-C677T, FOXO3. Honest effect sizes (not fear), actionability tiers, myth-flags overstated claims like MTHFR panic, and says plainly when a variant lacks real evidence. Not medical advice.

## Output

Returns a structured interpretation of the queried DNA variant including: honest effect size (not sensationalized), actionability tier indicating how much the variant should influence behavior, a myth-flag if the variant is commonly overstated in popular media, evidence quality rating, and a plain-language summary of what the variant actually means for longevity — with a clear disclaimer that this is not medical advice.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "lang": {
       "type": "string",
       "description": "en|es|fr|de|ja|zh|ko|pt|ar|hi (default en)"
      },
      "variants": {
       "type": "string",
       "description": "Comma-separated gene/variant IDs or rsIDs from a consumer DNA test, e.g. APOE-e4,MTHFR-C677T,FOXO3 (up to 8, required)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "results": [
   {
    "gene": "APOE",
    "input": "APOE-e4",
    "recognized": true,
    "effect_size": "One ε4 copy: ~2-3x Alzheimer's odds ratio vs ε3/ε3; two copies: ~8-12x — one of the largest common-variant effect sizes in human genetics, still a probabilistic shift, not a diagnosis",
    "actionability_tier": "well-replicated",
    "resolved_identifier": "rs429358 (APOE ε4 tagging SNP)"
   },
   {
    "input": "MTHFR-C677T",
    "myth_flag": {
     "the_myth": "Marketed as a serious \"detox\"/methylation defect requiring supplement protocols",
     "is_commonly_overstated_or_mythologized": true
    }
   }
  ],
  "variants_requested": [
   "APOE-e4",
   "MTHFR-C677T",
   "FOXO3"
  ]
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/longevitypulse-dna-variant-interpreter-e840847d/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from longevitypulse.theaslangroupllc.com](https://www.zero.xyz/host/longevitypulse.theaslangroupllc.com/llms.txt)