# LongevityPulse Longevity Drug Intelligence

> LongevityPulse Longevity Drug Intelligence is a paid API for AI agents from longevitypulse.theaslangroupllc.com, paid per call via x402, $0.2/call, status unknown (last checked 2026-09-14).

Returns evidence-graded pharmaceutical intelligence on longevity drugs (rapamycin, metformin, acarbose, senolytics, SGLT2 inhibitors, GLP-1 agonists) including human vs animal evidence and global availability.

## Facts

- Endpoint: GET https://longevitypulse.theaslangroupllc.com/api/longevity/longevity-drug
- Price: $0.2/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/longevitypulse-longevity-drug-intelligence-910565b7
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_PTsHqIsszAKJnA84mKEFM

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability longevitypulse-longevity-drug-intelligence-910565b7
```

Example prompt: What's the evidence grade for rapamycin as a longevity drug — does it have human clinical data or only animal studies, and is it available in the US?

## When to prefer this

Use this endpoint when an agent needs structured, evidence-graded intelligence specifically on pharmaceutical compounds studied for longevity or healthspan extension (rapamycin, metformin, senolytics, etc.), including differentiation between human and animal study data and global drug availability. Prefer over general medical databases when the focus is anti-aging/geroscience context rather than clinical treatment of disease.

## Known failure modes

- Drug not found in database — returns empty or error if compound is not tracked
- Ambiguous drug name — may return closest match or error if multiple compounds share a name
- No human evidence available — returns animal-only data with appropriate grading
- Unavailable in requested region — availability field may return null or restricted
- Rate limiting or payment failure — 402 response if payment not processed correctly

## How this service works

Longevity drug / anti-aging pharmaceutical intelligence (rapamycin, metformin, acarbose, senolytics, SGLT2 inhibitors, GLP-1 agonists) for longevity and health agents. Evidence-graded analysis of drugs studied for healthspan, with human-vs-animal evidence and global availability. Health intelligence, not medical advice.

## Output

A structured evidence-graded profile for the requested longevity drug, including human vs animal study evidence, mechanism of action, healthspan and aging-related effects, evidence quality grade, and global availability information. Explicitly framed as health intelligence rather than medical advice.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "drug": {
       "type": "string",
       "description": "Drug name — e.g. \"rapamycin\" | \"metformin\" | \"acarbose\" | \"dasatinib\" | \"fisetin\" | \"senolytics\" | \"SGLT2 inhibitor\" | \"empagliflozin\" | \"GLP-1\" | \"semaglutide\""
      },
      "lang": {
       "type": "string",
       "description": "en | es | fr | de | ja | zh | ko | pt | ar | hi (default: en)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "compound": "Rapamycin (Sirolimus)",
  "drug_class": "mTOR inhibitor (macrolide)",
  "fda_approved_for": "Organ transplant rejection prevention; certain cancers",
  "longevity_use_case": "mTOR inhibition mimics caloric restriction — the most robust longevity intervention across species. Shown to extend lifespan in every animal model tested.",
  "global_availability": {
   "prescription_status": "Prescription-only globally; Schedule F in US; available but off-label use varies by country"
  },
  "evidence_for_longevity": {
   "animal_evidence": {
    "lifespan_extension": "9-23% median lifespan extension in mice (ITP trials 2009, 2013, 2016) — even when started late in life"
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/longevitypulse-longevity-drug-intelligence-910565b7/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from longevitypulse.theaslangroupllc.com](https://www.zero.xyz/host/longevitypulse.theaslangroupllc.com/llms.txt)