# LongevityPulse Longevity Drug Intelligence

> LongevityPulse Longevity Drug Intelligence is a paid API for AI agents from longevitypulse.vercel.app, paid per call via x402, $0.2/call, status unknown (last checked 2026-09-15).

Returns evidence-graded longevity drug analysis covering human vs animal data, mechanisms, and global availability for pharmaceuticals like rapamycin, metformin, senolytics, and GLP-1 agonists

## Facts

- Endpoint: GET https://longevitypulse.vercel.app/api/longevity/longevity-drug
- Price: $0.2/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/longevitypulse-longevity-drug-intelligence-9663e9da
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_eP3u0eUi1uyWmWa3L3F6W

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability longevitypulse-longevity-drug-intelligence-9663e9da
```

Example prompt: What does the evidence show for rapamycin as a longevity drug — is the human evidence strong, how does it compare to the animal data, and can I actually get it in Europe?

## When to prefer this

Use this endpoint when you need structured, evidence-graded intelligence specifically about pharmaceuticals studied for longevity and healthspan extension — particularly when the user wants to know whether human trial data exists vs only animal studies, or wants to understand global availability. Prefer this over general medical databases when the focus is geroscience and anti-aging pharmacology.

## Known failure modes

- Unknown or unsupported drug name returns no results or an error
- Drug with only preclinical data may have sparse human evidence section
- Payment failure (402) if USDC payment not attached
- Network timeout if the vercel deployment is cold-starting

## How this service works

Longevity drug / anti-aging pharmaceutical intelligence (rapamycin, metformin, acarbose, senolytics, SGLT2 inhibitors, GLP-1 agonists) for longevity and health agents. Evidence-graded analysis of drugs studied for healthspan, with human-vs-animal evidence and global availability. Health intelligence, not medical advice.

## Output

Returns an evidence-graded profile of the requested longevity drug including mechanism of action, strength of human vs animal evidence, healthspan and lifespan effects observed in studies, known risks or considerations, and information on global pharmaceutical availability.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "drug": {
       "type": "string",
       "description": "Drug name — e.g. \"rapamycin\" | \"metformin\" | \"acarbose\" | \"dasatinib\" | \"fisetin\" | \"senolytics\" | \"SGLT2 inhibitor\" | \"empagliflozin\" | \"GLP-1\" | \"semaglutide\""
      },
      "lang": {
       "type": "string",
       "description": "en | es | fr | de | ja | zh | ko | pt | ar | hi (default: en)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "errors": {
     "type": "object",
     "description": "Documented error responses, keyed by HTTP status code",
     "additionalProperties": {
      "type": "object",
      "required": [
       "description"
      ],
      "properties": {
       "example": {
        "type": "object"
       },
       "description": {
        "type": "string"
       }
      }
     }
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "compound": "Rapamycin (Sirolimus)",
  "drug_class": "mTOR inhibitor (macrolide)",
  "fda_approved_for": "Organ transplant rejection prevention; certain cancers",
  "longevity_use_case": "mTOR inhibition mimics caloric restriction — the most robust longevity intervention across species. Shown to extend lifespan in every animal model tested.",
  "global_availability": {
   "prescription_status": "Prescription-only globally; Schedule F in US; available but off-label use varies by country"
  },
  "evidence_for_longevity": {
   "animal_evidence": {
    "lifespan_extension": "9-23% median lifespan extension in mice (ITP trials 2009, 2013, 2016) — even when started late in life"
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/longevitypulse-longevity-drug-intelligence-9663e9da/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from longevitypulse.vercel.app](https://www.zero.xyz/host/longevitypulse.vercel.app/llms.txt)