# magent ICC 2022 Systemic Mastocytosis Criteria Calculator > magent ICC 2022 Systemic Mastocytosis Criteria Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15). Evaluates caller-assigned ICC 2022 (Arber) criteria for systemic mastocytosis, returning whether the major criterion and/or sufficient minor criteria are met ## Facts - Endpoint: GET https://api.magentlab.com/api/calc/icc_sm - Price: $0.005/call - Payment: x402 - Status: unknown - Last checked: 2026-09-15 - Activations on Zero: 0 - Tags: x402 - Canonical page: https://www.zero.xyz/c/magent-icc-2022-systemic-mastocytosis-criteria-calculator-2ca73eb3 - Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_1IYAedNWXq2JKwBC5W7PV Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently. ## How to call it through Zero Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`): ```sh zero fetch --capability magent-icc-2022-systemic-mastocytosis-criteria-calculator-2ca73eb3 ``` Example prompt: This patient has major bone marrow mast cell infiltrates, KIT D816V mutation, and CD25 expression but serum tryptase is only 18 ng/mL — they also have an associated myeloid neoplasm. Do they meet ICC 2022 systemic mastocytosis criteria? ## When to prefer this Use this endpoint when you need to apply the specific ICC 2022 (Arber) systemic mastocytosis criteria, including the SM-AMN tryptase exclusion rule and CD30 as a minor criterion. Prefer this over other SM criteria tools when your workflow already has discrete boolean clinical findings (major infiltrates, morphology, KIT mutation, immunophenotype, tryptase, AMN status) pre-assigned by a clinician or upstream pipeline, and you need a reliable, auditable arithmetic evaluation. Do not use if you need WHO 5th edition (Khoury), Valent 2016, or cutaneous mastocytosis classification. ## Known failure modes - Missing required boolean parameters returns a validation error - Misunderstanding SM-AMN: caller may incorrectly include tryptase as a minor when associated_myeloid_neoplasm is true — the API enforces the exclusion - Endpoint does not interpret pathology, flow cytometry, or lab values — all criteria must be pre-assigned by the caller - Does not apply WHO 5th edition or Valent 2016 WHO SM criteria — wrong endpoint if those classifications are needed - Does not diagnose or output a diagnosis — result is a criteria evaluation only ## How this service works ICC 2022 systemic mastocytosis (Arber 2022). Met when major infiltrates (≥15 tryptase- and/or CD117-positive MCs in aggregates in BM or extracutaneous organ) alone, or ≥3 minors. Minors: >25% spindle or atypical immature morphology, KIT D816V or other activating KIT mutation, CD25/CD2/CD30, tryptase >20 ng/mL (not counted in SM-AMN). Not a diagnosis. Not Valent 2016 WHO SM. Not WHO 5th/Khoury. Not cutaneous mastocytosis only. magent does not read a biopsy or assay tryptase. ## Output Returns a structured result indicating whether the ICC 2022 (Arber) systemic mastocytosis major criterion is met, how many minor criteria are satisfied, whether overall SM criteria are fulfilled (major alone, or ≥3 minors), and whether the associated myeloid neoplasm flag suppressed the tryptase minor criterion (SM-AMN rule). ## Request schema (JSON Schema) ```json { "type": "object", "$schema": "https://json-schema.org/draft/2020-12/schema", "required": [ "input" ], "properties": { "input": { "type": "object", "required": [ "type", "method" ], "properties": { "type": { "type": "string", "const": "http" }, "method": { "enum": [ "GET", "HEAD", "DELETE" ], "type": "string" }, "headers": { "type": "object", "additionalProperties": { "type": "string" } }, "queryParams": { "type": "object", "required": [ "major_infiltrates", "atypical_or_spindle", "kit_activating", "cd2_cd25_or_cd30", "tryptase_gt_20", "associated_myeloid_neoplasm" ], "properties": { "kit_activating": { "type": "boolean", "description": "KIT D816V or other activating KIT mutation in bone marrow, blood, or an extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM minor; not codon-816-only). true or false. magent does not sequence KIT." }, "tryptase_gt_20": { "type": "boolean", "description": "Serum tryptase persistently >20 ng/mL as assigned by the caller (Arber 2022 ICC SM minor). Does not count when associated_myeloid_neoplasm is true (SM-AMN). true or false. magent does not assay tryptase." }, "cd2_cd25_or_cd30": { "type": "boolean", "description": "Mast cells express CD25, CD2, and/or CD30 in addition to mast-cell markers, as assigned by the caller (Arber 2022 ICC SM minor; ICC adds CD30). true or false. magent does not phenotype mast cells." }, "major_infiltrates": { "type": "boolean", "description": "Multifocal dense infiltrates of tryptase- and/or CD117-positive mast cells (≥15 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM major). true or false. magent does not read a biopsy." }, "atypical_or_spindle": { "type": "boolean", "description": ">25% spindle-shaped or atypical immature morphology in bone marrow or extracutaneous sections, as assigned by the caller (Arber 2022 ICC SM minor). true or false. magent does not read slides." }, "associated_myeloid_neoplasm": { "type": "boolean", "description": "Associated myeloid neoplasm (ICC SM-AMN) as assigned by the caller. When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagn … (truncated) ``` ## More - Live health (JSON, refreshed every minute): https://www.zero.xyz/c/magent-icc-2022-systemic-mastocytosis-criteria-calculator-2ca73eb3/health.json - [Zero catalog index](https://www.zero.xyz/llms.txt) - [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)