# magent Rome IV Reflux Hypersensitivity Calculator

> magent Rome IV Reflux Hypersensitivity Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).

Evaluates whether a patient meets the Rome IV diagnostic criteria for reflux hypersensitivity based on six caller-assigned boolean flags

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/rome_iv_reflux_hypersensitivity
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/magent-rome-iv-reflux-hypersensitivity-calculator-22e4911f
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_9G4oMw0pf-xF2v-lzrFEI

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability magent-rome-iv-reflux-hypersensitivity-calculator-22e4911f
```

Example prompt: My patient has retrosternal heartburn and chest pain, a normal endoscopy with no eosinophilic esophagitis, no esophageal motor disorder, and pH-impedance shows symptoms triggered by reflux events despite normal acid exposure — symptoms have been present for 8 months and criteria have been met for the last 4 months. Do they meet Rome IV reflux hypersensitivity criteria?

## When to prefer this

Use this endpoint when you need a fast, structured computation of Rome IV reflux hypersensitivity criteria (Aziz 2016) and the caller has already determined all six clinical flags from the patient record or history. Prefer this over manual checklist review when automating GI clinical decision support, research screening, or educational case classification. Do not use this to diagnose GERD/NERD as the primary tool, functional heartburn, or globus — those require different Rome IV calculators.

## Known failure modes

- Missing required boolean flags returns a validation error
- Misassignment of flags by caller leads to incorrect output (garbage-in, garbage-out)
- Endpoint does not validate clinical plausibility of flag combinations
- Network or payment (x402) failures may return HTTP 402 or 5xx errors

## How this service works

Aziz 2016 Rome IV reflux hypersensitivity. rome_iv_reflux_hypersensitivity is true iff retrosternal heartburn or chest pain, normal endoscopy without EoE, no motor disorder, reflux-triggered despite normal acid, 3- and 6-month timing. Caller assigns six flags. magent does not read pH-impedance or endoscopy. Antisecretory response does not exclude the diagnosis and is not a required flag. Not a diagnosis, not functional heartburn, not GERD/NERD as the primary tool, not globus.

## Output

Returns a boolean field `rome_iv_reflux_hypersensitivity` — true if all six Rome IV criteria for reflux hypersensitivity (Aziz 2016) are met, false otherwise. No clinical interpretation, history-taking, endoscopy reading, or pH-impedance analysis is performed; the caller is responsible for assigning all flags.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "retrosternal_heartburn_or_chest_pain",
      "normal_endoscopy_no_eoe",
      "no_major_esophageal_motor_disorder",
      "symptoms_triggered_by_reflux_despite_normal_acid_exposure",
      "fulfilled_last_3_months",
      "onset_at_least_6_months"
     ],
     "properties": {
      "fulfilled_last_3_months": {
       "type": "boolean",
       "description": "Criteria fulfilled for the last 3 months, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not take a history."
      },
      "normal_endoscopy_no_eoe": {
       "type": "boolean",
       "description": "Normal endoscopy and absence of evidence that eosinophilic esophagitis is the cause, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not read endoscopy."
      },
      "onset_at_least_6_months": {
       "type": "boolean",
       "description": "Symptom onset at least 6 months prior to diagnosis, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not take a history."
      },
      "no_major_esophageal_motor_disorder": {
       "type": "boolean",
       "description": "Absence of a major esophageal motor disorder, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not interpret manometry."
      },
      "retrosternal_heartburn_or_chest_pain": {
       "type": "boolean",
       "description": "Retrosternal symptoms including heartburn and chest pain, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not examine the patient."
      },
      "symptoms_triggered_by_reflux_despite_normal_acid_exposure": {
       "type": "boolean",
       "description": "Evidence that symptoms are triggered by reflux events despite normal acid exposure on pH or pH-impedance, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not parse traces."
      }
     }
    }
   },
   "additionalPro
… (truncated)
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/magent-rome-iv-reflux-hypersensitivity-calculator-22e4911f/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)