# MedAPI Evidence Synthesis

> MedAPI Evidence Synthesis is a paid API for AI agents from madapi.tempochan.xyz, paid per call via x402, $0.15/call, status unknown (last checked 2026-09-15).

Searches clinical trials and medical literature for a given question and returns AI-synthesized evidence with evidence level grading

## Facts

- Endpoint: POST https://madapi.tempochan.xyz/api/evidence
- Price: $0.15/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/medapi-evidence-synthesis-204a3bf3
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_nXL3foKjS41eFRPSMRQJP

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability medapi-evidence-synthesis-204a3bf3 -d '<json body>'
```

Example prompt: What does the clinical evidence say about metformin for weight loss in non-diabetic patients — search the trials and give me an evidence level summary.

## When to prefer this

Use this endpoint when you need both structured clinical trial data AND an AI-synthesized narrative summary with evidence grading in a single call. Prefer over raw PubMed or ClinicalTrials.gov APIs when you want pre-analyzed, evidence-leveled results without building your own synthesis pipeline.

## Known failure modes

- Empty or vague question returns no studies and low evidence level
- Question outside medical domain may return empty results
- LLM synthesis may time out on complex queries returning partial data
- Network or payment failure returns non-success response
- Malformed request missing required 'question' field returns 400 error

## How this service works

Drug data, adverse events, clinical trials, PubMed. AI-powered medical analysis. 17 endpoints. x402 on Base.

## Output

Returns a success flag, a list of matching clinical studies (as structured objects), a total study count, an evidence level string (e.g. 'moderate', 'high'), and an LLM-generated evidence synthesis analysis object.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "required": [
  "question"
 ],
 "properties": {
  "question": {
   "type": "string",
   "description": "question"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "object",
 "required": [
  "success"
 ],
 "properties": {
  "data": {
   "type": "object",
   "properties": {
    "total": {
     "type": "integer"
    },
    "studies": {
     "type": "array",
     "items": {
      "type": "object"
     }
    },
    "evidence_level": {
     "type": "string"
    }
   }
  },
  "success": {
   "type": "boolean"
  },
  "analysis": {
   "type": "object",
   "description": "LLM evidence synthesis"
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/medapi-evidence-synthesis-204a3bf3/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from madapi.tempochan.xyz](https://www.zero.xyz/host/madapi.tempochan.xyz/llms.txt)