# MIPSS70 Score Calculator for Primary Myelofibrosis (Guglielmelli 2018)

> MIPSS70 Score Calculator for Primary Myelofibrosis (Guglielmelli 2018) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).

Computes the Mutation-Enhanced International Prognostic Score System (MIPSS70) for transplant-eligible PMF patients, returning a total score, risk category, and Italian-cohort survival estimates.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/mipss70
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/mipss70-score-calculator-for-primary-myelofibrosis-guglielmelli-2018-34dd037d
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_bcbtcRRLpSTqOYm_X6MP2

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability mipss70-score-calculator-for-primary-myelofibrosis-guglielmelli-2018-34dd037d
```

Example prompt: Calculate the MIPSS70 score for my PMF patient: hemoglobin 8.5 g/dL, leukocytes 30×10^9/L, platelets 80×10^9/L, circulating blasts 3%, bone marrow fibrosis grade 2, constitutional symptoms present, no type 1/like CALR mutation, 2 HMR mutations — what's the risk category and expected survival?

## When to prefer this

Use this endpoint when you need the Guglielmelli 2018 MIPSS70 score specifically for transplant-age (≤70) PMF patients and have caller-assigned mutation data (CALR type, HMR count) and CBC values. Prefer this over MIPSS70-plus or version 2.0 endpoints when the original Italian-cohort survival benchmarks are required. Not suitable for post-ET/PV MF or when bone marrow grading has not yet been assigned by a pathologist.

## Known failure modes

- Missing required query parameters (leukocytes, platelets, blasts, fibrosis grade, symptoms, CALR status, HMR count) returns validation error
- Providing both hemoglobin_g_dl and hemoglobin_g_l simultaneously causes conflict error
- Out-of-range values (e.g. blasts >30%, fibrosis grade >3, leukocytes <0.5) may trigger validation rejection
- Omitting hemoglobin entirely may return an incomplete score or error
- x402 payment failure if USDC balance is insufficient

## How this service works

Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.

## Output

Returns a MIPSS70 integer total score (max 12), a risk category (Low: 0–1, Intermediate: 2–4, High: ≥5), and Italian-cohort survival statistics including median overall survival and 5-year OS rate (Low: 27.7 yr / 95%; Intermediate: 7.1 yr / 70%; High: 2.3 yr / 29%).

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "leukocytes_10e9_l",
      "platelets_10e9_l",
      "blasts_percent",
      "fibrosis_grade",
      "constitutional_symptoms",
      "calr_type1_like",
      "hmr_mutation_count"
     ],
     "properties": {
      "blasts_percent": {
       "type": "number",
       "description": "Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear."
      },
      "fibrosis_grade": {
       "type": "integer",
       "description": "WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow."
      },
      "hemoglobin_g_l": {
       "type": "number",
       "description": "Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0."
      },
      "calr_type1_like": {
       "type": "boolean",
       "description": "Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence."
      },
      "hemoglobin_g_dl": {
       "type": "number",
       "description": "Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin."
      },
      "platelets_10e9_l": {
       "type": "number",
       "description": "Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets."
      },
      "leukocytes_10e9_l": {
       "type": "number",
       "description": "Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes."
      },
 
… (truncated)
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/mipss70-score-calculator-for-primary-myelofibrosis-guglielmelli-2018-34dd037d/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)