# NCBI ClinVar Genetic Variants by Gene Symbol

> NCBI ClinVar Genetic Variants by Gene Symbol is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Fetches up to 10 ClinVar variant records (VCV accession, variant type, germline clinical significance, last evaluation date) for a given human gene symbol from NCBI ClinVar.

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/clinvar-genetic-variants?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ncbi-clinvar-genetic-variants-by-gene-symbol-fc78527a
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_LZotXTPFBXWFsn6BtHbf0

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ncbi-clinvar-genetic-variants-by-gene-symbol-fc78527a
```

Example prompt: Can you pull up the ClinVar variants for the BRCA1 gene — show me up to 8, including their VCV accessions, variant types, germline clinical significance, and last evaluation dates?

## When to prefer this

Use this endpoint when you need structured ClinVar germline clinical significance data (Pathogenic, Likely Pathogenic, etc.) quickly for a specific human gene symbol, without needing full variant names or protein-level details. Prefer this over direct NCBI API calls when you need a simple, pay-per-call interface returning up to 10 variants. Not suitable if you need protein change annotations, variant names, or somatic variants.

## Known failure modes

- Invalid or unrecognized gene symbol returns empty results or an error
- max parameter out of range (not 1–10) may return an error or be clamped to defaults
- Gene symbol with no ClinVar entries returns an empty list
- Rate limiting or upstream NCBI ClinVar API unavailability may cause timeout or error responses
- Genes with very large numbers of variants may only return a partial subset up to the configured max

## How this service works

NCBI ClinVar variants for a human gene symbol: VCV accession, variant type, germline clinical significance (e.g. Pathogenic, Likely pathogenic) and last evaluation date. Up to 10 variants per call. Variant names and protein changes are not included.

## Output

Returns a list of up to 10 ClinVar variant records for the specified gene, each containing: VCV accession number, variant type (e.g. single nucleotide variant, deletion), germline clinical significance (e.g. Pathogenic, Likely Pathogenic, Uncertain Significance), and last evaluation date. Variant names and protein changes are not included.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "gene"
     ],
     "properties": {
      "max": {
       "type": "string",
       "description": "How many variants, 1 to 10 (default 5)"
      },
      "gene": {
       "type": "string",
       "description": "Human gene symbol, letters, digits and hyphens, 2 to 20 characters"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ncbi-clinvar-genetic-variants-by-gene-symbol-fc78527a/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)