# NCBI ClinVar Variant Search via E-utilities

> NCBI ClinVar Variant Search via E-utilities is a paid API for AI agents from clonecho.builda.company, paid per call via x402, $0.02/call, status unknown (last checked 2026-09-15).

Searches NCBI ClinVar database for clinical genetic variants matching a query and returns matching UIDs via E-utilities esearch.

## Facts

- Endpoint: POST https://clonecho.builda.company/x402/s/ncbi-esearch-clinvar
- Price: $0.02/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ncbi-clinvar-variant-search-via-e-utilities-3d469d4f
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_vndH07QtAsfmx82L0BWA0

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ncbi-clinvar-variant-search-via-e-utilities-3d469d4f -d '<json body>'
```

Example prompt: Can you search ClinVar for pathogenic variants associated with BRCA2 and give me the matching UIDs?

## When to prefer this

Use this endpoint when you need to programmatically search NCBI ClinVar for clinical variant records and retrieve their UIDs, especially as the first step in a pipeline to fetch full variant details via NCBI E-utilities. Prefer this over manual ClinVar web searches when integrating genomic/clinical data lookups into automated workflows.

## Known failure modes

- Empty result set if query matches no ClinVar records
- Malformed or missing q parameter returns error
- NCBI E-utilities rate limiting or temporary unavailability
- Very broad queries may return truncated or paginated UID lists
- Special characters in query string may need URL encoding

## How this service works

Search NCBI ClinVar clinical variants and return matching UIDs for query {q} via E-utilities. Query: ?q= Returns JSON.

## Output

A JSON response containing matching ClinVar UIDs (record identifiers) for the given query, along with metadata such as the total count of results, returned from NCBI E-utilities esearch endpoint.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ncbi-clinvar-variant-search-via-e-utilities-3d469d4f/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clonecho.builda.company](https://www.zero.xyz/host/clonecho.builda.company/llms.txt)