# NCBI Conserved Domain Database (CDD) E-Search

> NCBI Conserved Domain Database (CDD) E-Search is a paid API for AI agents from clonecho.builda.company, paid per call via x402, $0.02/call, status unknown (last checked 2026-09-14).

Searches the NCBI Conserved Domain Database (CDD) and returns matching UID lists for a given protein-domain query via NCBI E-utilities.

## Facts

- Endpoint: POST https://clonecho.builda.company/x402/s/ncbi-esearch-cdd
- Price: $0.02/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ncbi-conserved-domain-database-cdd-e-search-83200a06
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_eMLjV-fst72Q9_VvDOH_U

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ncbi-conserved-domain-database-cdd-e-search-83200a06 -d '<json body>'
```

Example prompt: Search the NCBI Conserved Domain Database for conserved domains related to 'kinase' and give me the matching UIDs.

## When to prefer this

Use this endpoint when you need to programmatically search the NCBI Conserved Domain Database for protein domain UIDs based on a keyword or term. Prefer this over general NCBI search when you specifically need CDD-scoped results and UID lists for downstream bioinformatics workflows, domain annotation, or linking to CDD record details.

## Known failure modes

- Empty result set if query term matches no CDD entries
- Malformed or missing q parameter returns an error
- NCBI E-utilities rate limiting or downtime causing failure
- Very broad queries returning large UID lists that may be truncated
- Special characters in query string causing parsing errors

## How this service works

Search the NCBI Conserved Domain Database protein-domain database and return matching UIDs for query {q} via E-utilities. Query: ?q= Returns JSON.

## Output

A JSON response containing a list of NCBI CDD UIDs (numeric identifiers) matching the query term, along with metadata such as result count, as returned by the NCBI E-utilities esearch endpoint scoped to the CDD database.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ncbi-conserved-domain-database-cdd-e-search-83200a06/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clonecho.builda.company](https://www.zero.xyz/host/clonecho.builda.company/llms.txt)