# NCBI dbSNP Variant Summary Lookup

> NCBI dbSNP Variant Summary Lookup is a paid API for AI agents from proxy.suverse.io, paid per call via x402, $0.002/call, status unknown (last checked 2026-09-14).

Fetches allele information and global minor allele frequencies for a given SNP rsID from NCBI dbSNP, aggregated across major reference studies like 1000 Genomes and ExAC.

## Facts

- Endpoint: POST https://proxy.suverse.io/v1/data/suverse-bio-ncbi-snp-summary
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/ncbi-dbsnp-variant-summary-lookup-1c6dd7f7
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_qg-9zp75vJpYiEE7UXjZK

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability ncbi-dbsnp-variant-summary-lookup-1c6dd7f7 -d '<json body>'
```

Example prompt: Can you look up the allele frequencies and minor allele frequency for rs1045642 from dbSNP, including data from 1000 Genomes and ExAC?

## When to prefer this

Choose this endpoint when you need quick, keyless access to dbSNP variant summaries — specifically allele identities and global minor allele frequencies from reference studies — without managing NCBI API credentials. Ideal for bioinformatics agents, variant annotation pipelines, or pharmacogenomics workflows that need population frequency data on demand.

## Known failure modes

- Invalid or non-existent rsID returns an error or empty result
- NCBI E-utilities rate limiting or downtime causes request failure
- Malformed request body (missing rsID field) returns a validation error
- SNP with no frequency data in reference studies returns partial or null MAF fields
- Payment failure (x402) prevents access to the endpoint

## How this service works

Fetch dbSNP variant summary by rsID number: alleles and global minor allele frequencies across reference studies (1000 Genomes, ExAC, etc.). Keyless NCBI E-utilities. For agents querying SNP frequency data.

## Output

Returns a variant summary for the queried rsID including the reference and alternate alleles, global minor allele frequency (MAF), and per-study minor allele frequencies from major reference panels such as 1000 Genomes, ExAC, and similar population genomics resources.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method",
    "bodyType",
    "body"
   ],
   "properties": {
    "body": {
     "properties": {}
    },
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "POST",
      "PUT",
      "PATCH"
     ],
     "type": "string"
    },
    "bodyType": {
     "enum": [
      "json",
      "form-data",
      "text"
     ],
     "type": "string"
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/ncbi-dbsnp-variant-summary-lookup-1c6dd7f7/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from proxy.suverse.io](https://www.zero.xyz/host/proxy.suverse.io/llms.txt)