# OpenFDA Drug Adverse Event Reports via AgentDatum

> OpenFDA Drug Adverse Event Reports via AgentDatum is a paid API for AI agents from agentdatum.com, paid per call via x402, $0.01/call, status down (last checked 2026-10-21).

Fetches FDA adverse event and drug safety reports from the OpenFDA database, enriched and proxied through AgentDatum's intelligence layer

## Facts

- Endpoint: GET https://agentdatum.com/api/v1/d/openfda-drug?utm_source=zero.xyz
- Price: $0.01/call
- Payment: x402
- Status: down
- Last checked: 2026-10-21
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/openfda-drug-adverse-event-reports-via-agentdatum-2915747b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_y_huNT6_yRUCgSpdybo_s

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability openfda-drug-adverse-event-reports-via-agentdatum-2915747b
```

Example prompt: Pull the latest FDA adverse event reports for Duragesic from the OpenFDA drug database — I want to see patient reactions, seriousness flags, and any deaths reported.

## When to prefer this

Use this endpoint when you need structured FDA adverse event data for pharmacovigilance, drug safety research, or due diligence without setting up your own OpenFDA integration. It suits AI agents operating on x402 micropayment rails that need pay-per-call access to FDA drug safety records. Prefer this over direct OpenFDA calls when you want a pre-proxied, agent-friendly interface with consistent JSON wrapping and no API key management.

## Known failure modes

- Payment not provided or invalid x402 credentials — endpoint returns 402 Payment Required
- OpenFDA upstream unavailable — may return 5xx or empty results
- Query parameters malformed — returns 400 Bad Request
- Rate limiting if too many calls in short window
- Truncated or incomplete data if OpenFDA result set is very large

## How this service works

ADH 金融情报层：把 239 个原始数据源洗成带实体解析、时间同步、溯源与派生结论的情报（宏观regime / 加密尽调 / 事件窗口），免费注入你的 AI 上下文。Agent 走 x402 结算，人类订阅（PayPal）即将上线。

## Output

Returns a JSON object with a 'raw' field containing OpenFDA-formatted adverse event reports: metadata (total results, last updated, license), and an array of individual report records each containing sender info, patient data (drug taken, MedDRA reaction terms, sex, age, death details), seriousness flag, company number, receipt and receive dates, primary source qualification and country, and safety report ID.

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "raw": {
   "meta": {
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "results": {
     "skip": 0,
     "limit": 3,
     "total": 20692690
    },
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accur",
    "last_updated": "2026-07-30"
   },
   "results": [
    {
     "sender": {
      "senderorganization": "FDA-Public Use"
     },
     "patient": {
      "drug": [
       {
        "drugindication": "DRUG ABUSE",
        "medicinalproduct": "DURAGESIC-100",
        "drugcharacterization": "1",
        "drugauthorizationnumb": "019813",
        "drugadministrationroute": "041"
       }
      ],
      "reaction": [
       {
        "reactionmeddrapt": "DRUG ADMINISTRATION ERROR"
       },
       {
        "reactionmeddrapt": "DRUG ADMINISTRATION ERROR"
       }
      ],
      "patientsex": "1",
      "patientdeath": {
       "patientdeathdate": null,
       "patientdeathdateformat": null
      },
      "patientonsetage": "26",
      "patientonsetageunit": "801"
     },
     "serious": "1",
     "receiver": null,
     "companynumb": "JACAN16471",
     "receiptdate": "20080625",
     "receivedate": "20080707",
     "primarysource": {
      "qualification": "3",
      "reportercountry": "CANADA"
     },
     "safetyreportid": "5801206-7",
     "seriousnessdeath": "1",
     "transmissiondate": "20090109",
     "receiptdateformat": "102",
     "receivedateformat": "102",
     "transmissiondateformat": "102",
     "fulfillexpeditecriteria": "1"
    },
    {
     "sender": {
      "senderorganization": "FDA-Public Use"
     },
     "patient": {
      "drug": [
       {
        "drugindication": "DRUG ABUSE",
        "medicinalproduct": "DURAGESIC-100",
        "drugcharacterization": "1",
        "drugauthorizationnumb": "019813",
        "drugadministrationroute": "041"
       }
      ],
      "reaction": [
       {
        "reactionmeddrapt": "DRUG ADMINISTRATION ERROR"
       },
       {
        "reactionmeddrapt": "DRUG ADMINISTRATION ERROR"
       }
      ],
      "patientsex": "1",
      "patientdeath": {
       "patientdeathdate": null,
       "patientdeathdateformat": null
      },
      "patientonsetage": "26",
      "patientonsetageunit": "801"
     },
     "serious": "1",
     "receiver": null,
     "companynumb": "JACAN16471",
     "receiptdate": "20080625",
     "receivedate": "20080707"
… (truncated)
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/openfda-drug-adverse-event-reports-via-agentdatum-2915747b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from agentdatum.com](https://www.zero.xyz/host/agentdatum.com/llms.txt)