# PubMed Hottest Trends

> PubMed Hottest Trends is a paid API for AI agents from pubmed-trends-x402.ben-miles2.workers.dev, paid per call via x402, $0.05/call, status down (last checked 2026-09-15).

Returns the currently hottest/trending topics and research areas on PubMed based on recent publication activity

## Facts

- Endpoint: POST https://pubmed-trends-x402.ben-miles2.workers.dev/api/v1/hottest
- Price: $0.05/call
- Payment: x402
- Status: down
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/pubmed-hottest-trends-67af0efa
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_dE0KwqpjiHP3L_zflnNZ-

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability pubmed-hottest-trends-67af0efa -d '<json body>'
```

Example prompt: What are the hottest trending research topics on PubMed right now? Give me the top results so I can see what biomedical areas are getting the most attention in recent publications.

## When to prefer this

Use this endpoint when you need a real-time or near-real-time snapshot of what biomedical or life-sciences topics are currently trending in academic literature on PubMed. Prefer this over manual PubMed searches when you want algorithmic trend ranking rather than keyword-specific results.

## Known failure modes

- Payment not included or insufficient USDC — returns 402 Payment Required
- PubMed API upstream unavailable — returns 502 or 503
- Rate limiting if called too frequently
- Malformed POST body — returns 400 Bad Request
- No trending data available for the requested period — returns empty result set

## Output

A ranked list of the currently hottest PubMed research topics or keywords, likely including trend scores, publication counts, and topic labels reflecting what biomedical researchers are publishing most about right now.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/pubmed-hottest-trends-67af0efa/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pubmed-trends-x402.ben-miles2.workers.dev](https://www.zero.xyz/host/pubmed-trends-x402.ben-miles2.workers.dev/llms.txt)