# PubMed Hottest Papers Endpoint

> PubMed Hottest Papers Endpoint is a paid API for AI agents from pubmed.sekgen.xyz, paid per call via x402, $0.05/call, status down (last checked 2026-09-15).

Retrieves the highest-impact, most-cited, and trending biomedical papers from PubMed for a given research topic, scored and ranked by journal prestige, citation metrics, and MeSH relevance

## Facts

- Endpoint: POST https://pubmed.sekgen.xyz/api/v1/hottest
- Price: $0.05/call
- Payment: x402
- Status: down
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/pubmed-sekgen-xyz-e0d5d4a8
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_tMUsw5upnw4DmX1-ZbPPe

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability pubmed-sekgen-xyz-e0d5d4a8 -d '<json body>'
```

Example prompt: Pull the hottest, highest-impact PubMed papers on GLP-1 receptor agonists — I want them scored by journal prestige and citation metrics so I can see which ones are the most influential.

## When to prefer this

Use this endpoint when you need pre-scored, ranked key papers for a biomedical topic — particularly when you want journal prestige and citation signals combined, rather than just raw search results. Prefer this over the trend/count endpoints when the goal is paper-level discovery and quality assessment rather than publication volume analytics.

## Known failure modes

- Vague or overly broad query returns generic papers with low specificity
- Search term returns zero results if highly niche or misspelled
- Rate limiting or payment failure returns 402 or 429 error
- PubMed upstream unavailability causes timeout or 503
- Query that matches no MeSH terms may yield lower-quality scoring

## Output

A ranked list of key biomedical papers from PubMed, each scored by a composite metric incorporating journal prestige, citation counts, MeSH term relevance, and recency. Each paper entry includes title, authors, journal name, publication year, DOI/PMID, citation count, MeSH terms, and a relevance/impact score.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/pubmed-sekgen-xyz-e0d5d4a8/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pubmed.sekgen.xyz](https://www.zero.xyz/host/pubmed.sekgen.xyz/llms.txt)