# PubMed Trending Subtopics Analyzer

> PubMed Trending Subtopics Analyzer is a paid API for AI agents from pubmed.sekgen.xyz, paid per call via x402, $0.05/call, status unknown (last checked 2026-09-13).

Identifies and ranks the fastest-growing biomedical sub-topics within a research field using multi-year publication growth analysis from PubMed

## Facts

- Endpoint: GET https://pubmed.sekgen.xyz/api/v1/trending-subtopics
- Price: $0.05/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-13
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/pubmed-sekgen-xyz-fe017ed2
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_20wagf39Qu8bByqGKK0sO

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability pubmed-sekgen-xyz-fe017ed2
```

Example prompt: Which sub-topics within CRISPR gene editing research are growing fastest right now — give me the multi-year growth breakdown so I can see where the field is accelerating?

## When to prefer this

Use this endpoint when you need to understand the internal landscape of a research field — specifically which sub-areas are growing fastest over multiple years. Prefer this over single-topic trend endpoints when you want comparative subtopic intelligence within a domain, or over the emerging-topics scanner when you want depth within one field rather than breadth across domains.

## Known failure modes

- Empty or overly broad query returns no meaningful sub-topic differentiation
- Highly niche topic with sparse PubMed coverage may return unreliable growth rates
- Rate limiting or payment failure returns 402 error requiring x402 micropayment
- Query terms not recognized in PubMed MeSH taxonomy may yield unexpected subtopic groupings
- Network timeout if PubMed upstream is slow

## How this service works

Discover which biomedical sub-topics within a research field are growing fastest — multi-year growth analysis for clinical, pharmaceutical, genomics, and scientific domains

## Output

A ranked list of biomedical sub-topics within the queried research field, ordered by growth rate, with multi-year publication counts, CAGR values, and trend signals indicating which niches are accelerating fastest.

## Example request

```json
{
 "input": {
  "type": "http",
  "method": "GET",
  "queryParams": {
   "query": "oncology"
  }
 }
}
```

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {}
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/pubmed-sekgen-xyz-fe017ed2/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pubmed.sekgen.xyz](https://www.zero.xyz/host/pubmed.sekgen.xyz/llms.txt)