# PubMed Trends Pulse

> PubMed Trends Pulse is a paid API for AI agents from pubmed-trends-x402.ben-miles2.workers.dev, paid per call via x402, $0.02/call, status down (last checked 2026-09-15).

Analyzes and returns trending topics, keywords, or research patterns from PubMed biomedical literature

## Facts

- Endpoint: POST https://pubmed-trends-x402.ben-miles2.workers.dev/api/v1/pulse
- Price: $0.02/call
- Payment: x402
- Status: down
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/pubmed-trends-pulse-5d6e7520
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_r6ZfL9rwQlb34KzaIzJRq

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability pubmed-trends-pulse-5d6e7520 -d '<json body>'
```

Example prompt: What biomedical research topics are currently trending on PubMed — specifically around immunotherapy and cancer treatment?

## When to prefer this

Use this endpoint when you need a real-time or near-real-time pulse on what biomedical research topics are trending in PubMed literature, especially for surfacing emerging research signals, tracking keyword momentum, or identifying hot areas in life sciences without manually querying PubMed directly.

## Known failure modes

- Invalid or malformed query body returns 400 error
- Payment not included or insufficient USDC causes 402 Payment Required
- Rate limiting or worker timeout returns 503
- Query topic too broad or ambiguous returns empty or low-confidence trends
- PubMed upstream unavailable causes 502 or 504

## Output

Returns a pulse snapshot of trending PubMed research topics, including rising keywords, publication frequency signals, and emerging research areas based on recent literature activity.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/pubmed-trends-pulse-5d6e7520/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pubmed-trends-x402.ben-miles2.workers.dev](https://www.zero.xyz/host/pubmed-trends-x402.ben-miles2.workers.dev/llms.txt)