# Reactome Biological Pathways Lookup by Gene

> Reactome Biological Pathways Lookup by Gene is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-01).

Returns all Reactome biological pathways associated with a given gene symbol or UniProt accession, including pathway IDs, names, disease flags, and links.

## Facts

- Endpoint: GET https://saylorinnovations.com/api/bio/pathways/:id?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-01
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/reactome-biological-pathways-lookup-by-gene-888fcd2b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_tJzkMEtnbKoVOGI_BHYzl

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability reactome-biological-pathways-lookup-by-gene-888fcd2b
```

Example prompt: What biological pathways is the gene TP53 involved in according to Reactome? Include any disease-flagged pathways and their Reactome IDs.

## When to prefer this

Use this endpoint when you need structured Reactome pathway annotations for a specific gene or protein, including disease pathway flags and direct Reactome links. Prefer this over manual Reactome web queries when automating bioinformatics pipelines, enrichment analyses, or building gene-pathway knowledge graphs. It is especially useful for agents needing machine-readable pathway data with UniProt or gene symbol input without requiring direct Reactome API integration.

## Known failure modes

- Unknown gene symbol or UniProt accession returns empty results or 404
- Invalid organism taxon ID returns error or defaults to human unexpectedly
- Network timeout for genes involved in very large numbers of pathways
- Ambiguous gene symbols that map to multiple genes may return merged or incorrect results
- Non-human organism with limited Reactome coverage may return sparse results

## How this service works

Biological Pathways for a Gene (Reactome). Biological pathways a gene or protein takes part in (Reactome), by gene symbol or UniProt accession: every pathway with its Reactome id, name, disease flag and link. Human by default, ?organism= taxon for others. Reactome, CC BY 4.0.

## Output

A list of pathways the gene or protein participates in, each including a Reactome pathway ID, human-readable pathway name, a boolean disease flag indicating whether the pathway is disease-associated, a direct Reactome link, and organism context.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/reactome-biological-pathways-lookup-by-gene-888fcd2b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from saylorinnovations.com](https://www.zero.xyz/host/saylorinnovations.com/llms.txt)