# Rhea Biochemical Reaction Search

> Rhea Biochemical Reaction Search is a paid API for AI agents from clonecho.builda.company, paid per call via x402, $0.02/call, status unknown (last checked 2026-09-14).

Search the Rhea expert-curated database of biochemical reactions by keyword query

## Facts

- Endpoint: POST https://clonecho.builda.company/x402/s/rhea-reaction-search
- Price: $0.02/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-14
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/rhea-biochemical-reaction-search-69e7dd73
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_-jBhaO-KkhMFzK__aNtWo

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability rhea-biochemical-reaction-search-69e7dd73 -d '<json body>'
```

Example prompt: Can you search the Rhea biochemical reactions database for reactions involving pyruvate? I want to see what enzyme-curated reactions are listed for it.

## When to prefer this

Use this endpoint when you need to look up expert-curated biochemical reactions by keyword — especially for metabolite names, enzyme names, or compound names — and need structured, authoritative data from the Rhea database. Prefer over general web search when you need machine-readable biochemical reaction data with standardized identifiers.

## Known failure modes

- Empty result set if keyword matches no reactions in the Rhea database
- Missing or empty q parameter returns error or all/no results
- Network timeout for very broad queries returning large result sets
- HTTP 402 payment required if USDC payment not provided
- Malformed query string causing parse error

## How this service works

Search the Rhea expert-curated database of biochemical reactions by keyword {q}. Query: ?q= Returns JSON.

## Output

A JSON array or object containing matching biochemical reactions from the Rhea expert-curated database, including reaction identifiers, names, participants (substrates and products), and associated metadata for each reaction matching the keyword query.

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/rhea-biochemical-reaction-search-69e7dd73/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clonecho.builda.company](https://www.zero.xyz/host/clonecho.builda.company/llms.txt)