# Saylor Innovations Bioinformatics: Gene Variant List by Clinical Significance (ClinVar)

> Saylor Innovations Bioinformatics: Gene Variant List by Clinical Significance (ClinVar) is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.003/call, status unknown (last checked 2026-10-01).

Fetches ClinVar variants for a gene filtered by clinical significance, returning total count plus latest records with classification, review stars, conditions, and protein change

## Facts

- Endpoint: GET https://saylorinnovations.com/api/bio/variants?utm_source=zero.xyz
- Price: $0.003/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-01
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/saylor-innovations-bioinformatics-gene-variant-list-by-clinical-8bbc5660
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_c0tkinY9JlUhVSuujgRAN

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability saylor-innovations-bioinformatics-gene-variant-list-by-clinical-8bbc5660
```

Example prompt: Can you pull up all pathogenic variants for the BRCA1 gene from ClinVar, including their classifications, review stars, associated conditions, and any protein changes?

## When to prefer this

Use this endpoint when you need structured ClinVar variant data for a specific gene filtered by clinical significance category. It is ideal for genomic research workflows, clinical decision support tools, or bioinformatics agents that need to quickly surface pathogenic, benign, or uncertain variant records without building a direct NCBI ClinVar API integration. Prefer this over raw NCBI queries when you want pre-filtered, pay-per-call simplicity with protein change and condition metadata bundled in one response.

## Known failure modes

- Invalid or unrecognized gene symbol returns found=false with empty variants array
- Invalid significance value returns an error or empty result
- Gene with no ClinVar entries returns found=false
- NCBI ClinVar upstream outage may cause timeout or empty response
- Missing required gene parameter returns a validation error

## How this service works

Gene Variant List by Clinical Significance (ClinVar). ClinVar variants for a gene, filtered by clinical significance (pathogenic, likely_pathogenic, uncertain, benign, likely_benign, conflicting): total count in ClinVar plus the latest records with classification, review stars, conditions and protein change. NCBI ClinVar, public domain.

## Output

Returns a JSON object with a 'found' boolean, the total count of matching variants in ClinVar, and an array of variant records each containing clinical classification, review star rating, associated conditions, and protein change information

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "POST",
      "PUT",
      "PATCH",
      "DELETE",
      "HEAD"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "properties": {
      "gene": {
       "type": "string",
       "description": "gene symbol (query)"
      },
      "significance": {
       "type": "string",
       "description": "pathogenic | likely_pathogenic | uncertain | benign | likely_benign | conflicting (query, optional)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "json"
    },
    "example": {
     "type": "object",
     "required": [
      "found"
     ],
     "properties": {
      "found": {
       "type": "boolean"
      },
      "variants": {
       "type": "array",
       "items": {
        "type": "object"
       }
      },
      "total_in_clinvar": {
       "type": "number"
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/saylor-innovations-bioinformatics-gene-variant-list-by-clinical-8bbc5660/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from saylorinnovations.com](https://www.zero.xyz/host/saylorinnovations.com/llms.txt)